Project Grant R35ES037866
- Federal Grant Award Summary The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $18.3 million through the Aging Research program (CFDA 93.866) to investigate the relationship between metal exposures and Alzheimer's disease and related dementia (AD/ADRD) risk in diverse U.S. populations. Beginning February 1, 2026, and extending through January 31, 2030, this project leverages two major NIH-funded epidemiological cohorts—the Atherosclerosis Risk...
- Federal Project Grant Award Summary Boston University Medical Campus received a $147,486 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded November 1, 2025, with completion targeted for August 31, 2028. This research project will investigate the neurodevelopmental impacts of early-life exposure to ferroalloy metal mixtures—including manganese, lead, chromium, and copper—on adolescent cognitive...
- Federal Project Grant Award Summary New York University School of Medicine received a $2.52M Project Grant from the National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113), awarded September 16, 2025, with completion targeted for September 15, 2029. This research project investigates the molecular mechanisms underlying chromium(VI) carcinogenesis, specifically examining the role of Neural Precursor Cell Expressed Developmentally Down-Regulated...
- Federal Grant Award Summary New York University School of Medicine received a $1,124,358 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded August 22, 2025, with a completion date of May 31, 2030. The grant funds research investigating the effects of hexavalent chromium (CR(VI)) exposure on skeletal muscle differentiation and regeneration. The research addresses a significant knowledge gap regarding...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113) awarded $249,000 to the University of North Carolina at Chapel Hill on August 13, 2025, for a research project extending through July 31, 2028. This Project Grant supports longitudinal research characterizing the early life chemical exposome and its impact on structural and functional brain development in children from birth through age five. The research...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $1,006,211 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded February 17, 2026, with completion targeted for January 31, 2034. The grant supports research to elucidate how environmental chemical exposures affect mitochondrial function and interact with genetic mitochondrial disease conditions. The...
- Federal Grant Award Summary New York University School of Medicine received a $10.9 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 15, 2025, and scheduled for completion by September 14, 2029. This translational research project investigates the accumulation of micro- and nanoplastic particles (MNPs) in mammalian tissues, addressing a critical public health gap regarding human...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Icahn School of Medicine at Mount Sinai a $498,000 Project Grant under the Environmental Health program (CFDA 93.113) on August 25, 2025, with completion targeted for July 31, 2028. This R00 Career Transition Award supports the investigator's transition to an independent researcher studying how prenatal exposure to fine particulate air pollution (PM2.5) influences neurodevelopmental outcomes in...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $390,337 Project Grant to Icahn School of Medicine at Mount Sinai on July 25, 2025, under the Environmental Health program (CFDA 93.113). The award supports development and expansion of the PFAS Exposure Burden Calculator, a novel research tool designed to standardize measurement of cumulative per- and polyfluoroalkyl substance (PFAS) exposure across epidemiological studies and...
- Summary of Federal Project Grant Award Arizona State University received a $430,625 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded May 15, 2026, with completion targeted for May 14, 2028. The grant funds a comprehensive research study to detect and quantify micro- and nanoplastics (MNPs) in human brain tissue using five complementary detection methods applied to postmortem brain samples from 140...
The National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113) awarded $942,408 to The Trustees of Columbia University in the City of New York, Health Sciences Division on June 1, 2026, for an eight-year research initiative through May 31, 2034. This project, titled "Revolutionary Environmental Metalloproteomics for Aging Science and Prevention," develops novel mass spectrometry-based biomarkers and analytical methodologies to quantify metal-protein interactions and assess metal burden in biological samples, with particular emphasis on brain-derived extracellular vesicles as surrogate markers for central nervous system tissue. The research addresses critical gaps in understanding how essential metals (copper, iron, zinc) and neurotoxic metals (lead) affect protein function and contribute to age-related cognitive decline and dementia, particularly in individuals with genetic risk factors. The project delivers three integrated research components: development and validation of innovative metalloproteomics biomarkers (Area 1); observational epidemiological studies analyzing metal-protein associations with brain health outcomes using existing cohort data and advanced neuroimaging (Area 2); and experimental investigations leveraging clinical trial data, including the TACT2 chelation therapy trial, to examine causal mechanisms between metal burden reduction and cognitive outcomes (Area 3). By translating metalloproteomics technology into clinical research applications, this award advances the NIEHS mission to understand environmental health exposures and their biological mechanisms while generating tools and evidence to reduce disease burden and promote healthy aging.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $942.4k | 6/3/26 |