Project Grant R21EB039265
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Pittsburgh $235,550 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop programmable ultrasound-leveraged site-specific exosomes for precise therapeutic delivery to the brain. The project addresses spatial and temporal control of drug delivery in neurological disorders by engineering exosomes—biocompatible...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Illinois $757,625 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) for the development of multiplexed connectomic mapping methods for brain microcircuits. The funded work will develop an integrated platform combining computational design of epitope-defined affinity binders for cell-type identification, electron microscopy-compatible...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Research Foundation For The State University Of New York $244,500 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and mechanistically characterize sulfonium-based lipid nanoparticles for mRNA and CRISPR/Cas9 delivery to the brain. The award funds research to elucidate how sulfonium-based lipid nanoparticles mediate...
- The National Institute of General Medical Sciences awarded the University of Illinois $1,385,652 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop in vivo metabolic tagging and targeting of long-circulating red blood cell biomembranes. The project aims to create a platform technology for metabolic tagging of red blood cell (RBC) membranes using unnatural sugars and subsequent targeting of molecular imaging and therapeutic cargo via click...
- The National Institute of Neurological Disorders and Stroke awarded The Broad Institute, Inc. $404,282 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to engineer transferrin receptor 1 (TFR1) binding adeno-associated virus (AAV) capsids that evade pre-existing neutralizing antibodies while maintaining central nervous system delivery capability. The funded research addresses a critical barrier to AAV gene therapy for...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $708,389 on September 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design and implement short interfering RNA (siRNA) conjugates as tools for central nervous system cell-specific gene modulation. The project focuses on developing siRNA conjugates that enable targeted gene knockdown in specific CNS cell types,...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of Illinois $395,787 on May 1, 2026, under the Engineering program (CFDA 47.041) to interrogate the fundamental mechanisms of mechanical neuromodulation at the nanoscale. The research will develop a laboratory tool that applies highly controlled mechanical forces to specific regions of individual neurons and monitors their response in real time, using light to...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded Trustees of Boston University $449,625 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance targeted delivery of intracellular protein therapeutics using virus-like particles derived from retroviruses. The research focuses on developing design principles for next-generation virus-like particles (VLPs) that enhance cell-specific...
- The National Institute of Dental and Craniofacial Research awarded the University of Illinois $135,522 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and optimize EVOLVE, a force-free engineering platform for loading therapeutic cargo into extracellular vesicles for clinical delivery applications. The project centers on a novel mechanism called endovesiclosis, in which cationic-arginine-functionalized iron oxide nanoparticles bind therapeutic...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded The Ohio State University $424,333 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a bioengineered blood-brain barrier-on-a-chip microphysiological system for improved drug screening in primary brain tumors. The project addresses the challenge of modeling glioblastoma cellular...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of Illinois $226,160 on August 17, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to engineer virus-like particles (VLPs) for systemic and targeted RNA delivery to the brain across the blood-brain barrier. The project will develop and optimize VLPs capable of efficient, brain-targeted RNA delivery by engineering them to recognize blood-brain barrier receptors involved in vector transcytosis and establishing a scalable, iterative screening platform to evolve receptor-targeted VLPs. The work aims to create a toolkit for systemic VLP vectors applicable to diverse cargoes such as gene-editing ribonucleoproteins and targets beyond the central nervous system, addressing current delivery limitations faced by existing systems including lipid nanoparticles. Work is performed at the University of Illinois in Urbana, Illinois, with a period of performance through April 30, 2029. This is a Project Grant, an assistance type supporting hypothesis-driven research related to discovery, design, development, validation, and application of biomedical imaging and bioengineering technologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $226.2k | 8/14/26 |