Project Grant R21EB039194
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Illinois $226,160 on August 17, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to engineer virus-like particles (VLPs) for systemic and targeted RNA delivery to the brain across the blood-brain barrier. The project will develop and optimize VLPs capable of efficient, brain-targeted RNA delivery by engineering them to recognize...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $570,612 on April 7, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop advanced volumetric ultrasound systems for functional imaging and multi-targeted closed-loop neuromodulation. The project addresses current limitations in ultrasonic neuromodulation by moving beyond MRI-dependent targeting...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh $587,678 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to elucidate immune cell trafficking and biodegradation of bioscaffolds implanted in brain tissue using multi-color 19F magnetic resonance imaging. The research visualizes the spatio-temporal dynamics of peripheral immune cell accumulation and invasion into...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $232,605 to the University of Pennsylvania on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), a Project Grant assistance type. The recipient will isolate and characterize microglial-derived extracellular vesicles as biomarkers for traumatic brain injury. The...
- The National Institute of Biomedical Imaging and Bioengineering awarded Case Western Reserve University $531,541 on April 23, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop contrast-enhanced ultrasound imaging biomarkers for predicting nanoparticle therapeutic accumulation in tumors. The research develops a series of contrast-enhanced ultrasound biomarkers that correspond to increased vascular permeability...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $154,274 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop small-focus transparent transducers for transcranial ultrasound stimulation in mice. The research addresses the absence of noninvasive tools for focal brain-wide neuromodulation, a limitation that constrains circuit-based understanding of neural...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Research Foundation For The State University Of New York $244,500 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and mechanistically characterize sulfonium-based lipid nanoparticles for mRNA and CRISPR/Cas9 delivery to the brain. The award funds research to elucidate how sulfonium-based lipid nanoparticles mediate...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $542,947 on March 3, 2026, to develop fully non-invasive transcranial functional ultrasound imaging for adult humans under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The project applies signal processing and machine learning techniques to enhance low-velocity blood flow imaging through the skull, translating functional ultrasound...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $229,820 on June 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286, Project Grant R21EB038058) to develop and validate magnetic resonance imaging tools for real-time monitoring of ultrasound-mediated gas delivery. The funded research synthesizes and characterizes hyperpolarized xenon-129-filled...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of Pittsburgh $235,550 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop programmable ultrasound-leveraged site-specific exosomes for precise therapeutic delivery to the brain. The project addresses spatial and temporal control of drug delivery in neurological disorders by engineering exosomes—biocompatible extracellular vesicles—as delivery vehicles that cross physiological barriers without disrupting the blood-brain barrier. The approach masks exosome surface proteins with albumin-binding domains via a tobacco etch virus protease-cleavable linker to prevent nonspecific uptake during systemic circulation. Low-intensity focused ultrasound induces spatially confined protease expression in targeted brain vasculature, enabling localized exosome unmasking and selective payload delivery. The proposal includes two specific aims: engineering albumin-binding domain-masked, green fluorescent protein-labeled exosomes and using focused ultrasound to induce localized protease expression in brain endothelial cells to enable and evaluate site-specific delivery. The award runs through July 31, 2029, with performance at the University of Pittsburgh in Pittsburgh, Pennsylvania. This is a Project Grant, the assistance type for hypothesis-driven biomedical research under NIBIB's core mission to develop technologies for disease prevention, detection, diagnosis, and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $235.6k | 7/29/26 |