Project Grant DP2DA068576
- The National Institute of General Medical Sciences awarded the University of Illinois $113,211 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop mass spectrometry-based instrumentation and computational tools for spatiotemporal neuropeptidomics with isomer-resolved capabilities. The work will map neuropeptide distribution and release with high spatial and temporal resolution and increased throughput, creating new molecular signatures of...
- The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute in Seattle, WA. The award, spanning September 2024 to September 2027, aims to develop two "exa-scale" (extremely high-throughput) tissue readout methods to transform the study of the brain. The first method will enable highly multiplexed molecular mapping of individual proteins across entire brains at the...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded the University of Illinois $225,439 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate animal models of hypothalamic hamartoma. The project uses novel viral-transgenic strategies and CRISPR gene editing to create sporadic, mosaic disruption of sonic hedgehog signaling in mice with...
- The University of Illinois was awarded a $1,372,964 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The 3-year grant, effective September 1, 2023, aims to establish a biochemical process for expanding biological samples to enable label-free molecular imaging at the subcellular level using mass spectrometry. The key objectives are to: (1) develop a tissue polymerization and expansion protocol optimized for lipid mass...
- The National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) awarded $361,125 to the University of California, Berkeley on September 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) as a project grant. The award funds a targeted planning project to establish a functional connectomics paradigm combining ultra-fast two-photon voltage imaging (2P-FACED) with two-photon optogenetic...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Neurological Disorders and Stroke awarded the University of Illinois $407,211 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on neural progenitor cell differentiation and therapeutic mechanisms in multiple sclerosis. The research investigates a natural product-derived Notch1 signaling inhibitor, (+)-3D-spiro-oxindole, designed to promote neural progenitor and stem...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded the University of Illinois $526,483 on May 14, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop enhanced epigenome editing technologies for controlling mammalian gene expression. The award funds development of a toolkit of programmable epigenome editors capable of activating gene expression in vivo through three integrated aims. Aim 1...
- The National Institutes of Health (NIH) Office of the Director awarded a $1,345,424 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The grant, effective September 10, 2024 through September 9, 2027, aims to develop a novel genetically encoded "protein ticker tape" system that enables long-term, brain-wide recording of single-cell physiology in live mice without external interfacing. The technology will leverage...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Illinois $757,625 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) for the development of multiplexed connectomic mapping methods for brain microcircuits. The funded work will develop an integrated platform combining computational design of epitope-defined affinity binders for cell-type identification, electron microscopy-compatible multiplexed fluorescence imaging to link molecular profiles with anatomical structure, and visualization of long-range axonal inputs into microcircuits. The platform aims to achieve nanoscale-resolution mapping of brain microcircuits with multiplexed molecular annotation and cross-scale connectivity information, designed to support discovery of circuit- and cell-type-specific therapeutic targets for more precise modulation of maladaptive brain responses in pathological conditions. Performance occurs in Illinois and extends from September 1, 2026, through July 31, 2031. This is a Project Grant, a standard assistance type under the Trans-NIH Research Support program, which covers multiple offices in the NIH Office of the Director offering assistance awards and supplements. Awards under this program are subject to OMB 2 CFR 200 audit requirements and generally require grantees to retain financial and programmatic records for three years from the date of annual financial status reporting.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $757.6k | 8/25/26 |