Project Grant R01EB037413
- Federal Project Grant Award Summary Case Western Reserve University received $630,108 in Project Grant funding from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded March 13, 2026, with a completion date of February 28, 2030. The award supports theranostic research developing combined fluorescence image-guided surgery (FIGS) and photothermal therapy (PTT) approaches for breast cancer treatment. The research centers on optimizing...
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering awarded $630,000 to the University of California, Los Angeles under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) on September 1, 2025, with a completion date of August 31, 2028. This three-year project develops light-activated site-specific conjugation (LASIC) technology to advance the clinical translation of catheter-directed...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the University of Pennsylvania $999,818 on August 11, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a novel biomedical imaging technology for early-stage hepatocellular carcinoma (HCC) detection. The project, titled "Early-Stage Detection of Hepatocellular Carcinoma with...
- Federal Grant Award Summary Case Western Reserve University received a $109,076 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 30, 2025 through September 29, 2029. The research focuses on developing advanced computational methods, including deep learning algorithms, to detect and characterize small, low-density "sub-Agatston" coronary artery calcifications on cardiac CT...
- Federal Project Grant Award Summary The University of Miami's Office of Research Administration - School of Medicine received a $1.28 million Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, effective August 1, 2025, through April 30, 2029, supports research investigating magnetic particle imaging (MPI) technology for...
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Washington University a $598,134 Project Grant on August 5, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop sensing collimator technology for ultrasensitive Single Photon Emission Computed Tomography (SPECT) imaging of targeted radiopharmaceutical therapies. The four-year project, concluding...
- Federal Project Grant Award Summary Case Western Reserve University received a $147,486 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2025, with completion targeted for May 31, 2027. The award supports the development of a pathologically interpretable computational imaging predictor to identify rectal cancer patients exhibiting complete response (CR) to total neoadjuvant therapy (TNT) who are candidates for...
- Federal Project Grant Award Summary Case Western Reserve University received a $695,000 CAREER award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041, Engineering program) on July 1, 2025, with a completion date of June 30, 2030. The project delivers fundamental research into the structural properties and intracellular behavior of DNA origami nanoparticles—synthetic deoxyribonucleic acid (DNA) nanostructures...
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $109,076 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective January 10, 2026, with an ultimate completion date of September 9, 2028. The award supports research and development of Magnetic Resonance Fingerprinting (MRF) technology for characterization and prediction of glioblastoma infiltration. The...
- Federal Project Grant Award Summary Case Western Reserve University received a $431,750 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 1, 2026, with an ultimate completion date of February 28, 2031. The award funds data-driven research to characterize the structural dynamics and molecular mechanisms of the estrogen receptor (ER), a critical target for developing next-generation...
Case Western Reserve University received a $531,541 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective April 23, 2026 through January 31, 2030. The grant funds research to develop contrast-enhanced ultrasound (CEUS) imaging biomarkers capable of identifying increased vascular permeability in target tissues, with the primary objective of creating a predictive method for therapeutic nanoparticle accumulation in tumors. This research addresses the clinical challenge of heterogeneous tumor vascular architecture that has resulted in inconsistent outcomes from nanoparticle-based chemotherapeutics delivered via the enhanced permeability and retention (EPR) effect. The project will build upon existing dynamic CEUS protocols used clinically with microbubbles by developing a novel imaging agent to overcome size limitations, ultimately enabling clinicians to personalize therapeutic regimens based on individual tumor vascular characteristics. The anticipated deliverable is a non-invasive, real-time imaging methodology that can categorize vascular permeability extent, potentially reducing healthcare costs and adverse medication effects across diseases involving pathologically permeable vasculature. Research will be conducted at the University's Cleveland, Ohio facility in affiliation with University Hospitals of Cleveland.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $531.5k | 4/27/26 |