Project Grant R21EB038569
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $236,834 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a novel magnetic resonance spectroscopy imaging sequence for non-invasive assessment of skeletal muscle metabolites in type 2 diabetes. The project develops a metabolite cycled semi-laser localized 4D echo planar...
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $138,813 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to support Dr. Mai Thuan Huynh's transition to independent investigator status in metabolism and molecular imaging research. The award funds design, synthesis, and validation of advanced carbon tracers to image...
- The National Institute of Biomedical Imaging and Bioengineering, a component of the Department of Health and Human Services National Institutes of Health, awarded $184,063 to the University of Texas at San Antonio on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of forced-dimerization activated photoacoustic aptamer switch sensors (FDA-PASS), optical probes designed to enable...
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $536,853 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development and validation of a comprehensive 7 Tesla MRI framework for simultaneous high-resolution mapping of brain iron and myelin in mesoscale brain structures. The project integrates three complementary...
- The National Institute of General Medical Sciences awarded Adamas Nanotechnologies, Inc. $306,872 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a real-time measurement system for mitochondrial temperature using fluorescent nanodiamonds with nitrogen-vacancy centers. The Phase I effort will explore the feasibility of using nitrogen-vacancy centers in nanodiamonds in combination with a highly sensitive lock-in camera to monitor the...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Arlington $339,676 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop light-responsive osmium compounds as metallo-reagents for biomedical imaging and photoactivation. The project develops osmium-based...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $486,805 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop margination-mediated delivery and glutathione-triggered release mechanisms enabled by renal-clearable gold nanoparticles for fluorescence-guided surgery of brain metastases. The project addresses a clinical gap: current...
- The National Institute on Aging awarded Northwestern University $773,538 on April 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a Phase III multi-centered double-blinded randomized clinical trial evaluating nicotinamide riboside (NR) as a therapeutic intervention for lower extremity peripheral artery disease. The trial, titled "Nicotinamide Riboside to Improve Functioning in PAD: The NICE Trial," will test whether oral NR supplementation improves walking capacity...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University Medical Center $393,750 on August 17, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a double saturation technique for chemical exchange saturation transfer (CEST) imaging that enhances glycogen quantification at clinical 3T MRI field strength. The funded work develops DSP-CEST, a novel quantification method that...
The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $207,500 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286, Assistance Listing project grant R21EB038569) to develop hyperpolarized 15N-labeled nicotinamide riboside as a magnetic resonance spectroscopy probe for monitoring NAD+ and NADH levels in vivo. The funded research addresses the diagnostic value of the NAD+/NADH redox ratio, which decreases in mitochondrial dysfunction diseases including diabetes, cancer, and ischemic attack, and declines with age. Currently no non-invasive, spatially resolved analytical or spectroscopic technique enables in vivo assessment of NAD+ metabolism and the NAD+/NADH ratio across tissues. The project will synthesize and hyperpolarize 15N-labeled nicotinamide riboside using dissolution dynamic nuclear polarization and 15N enrichment to improve detection sensitivity. The investigator will conduct hyperpolarized 15N magnetic resonance spectroscopy studies in cells and in vivo using a renal ischemia rat model to demonstrate that the hyperpolarized probe can assess NAD+ and NADH levels independently and in real-time, monitoring their ratio. Work is performed at The University of Texas Southwestern Medical Center in Dallas, Texas. The period of performance runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $207.5k | 8/18/26 |