Project Grant K01EB039883
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $236,834 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a novel magnetic resonance spectroscopy imaging sequence for non-invasive assessment of skeletal muscle metabolites in type 2 diabetes. The project develops a metabolite cycled semi-laser localized 4D echo planar...
- The National Institute of Biomedical Imaging and Bioengineering, a component of the Department of Health and Human Services National Institutes of Health, awarded $184,063 to the University of Texas at San Antonio on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of forced-dimerization activated photoacoustic aptamer switch sensors (FDA-PASS), optical probes designed to enable...
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $207,500 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286, Assistance Listing project grant R21EB038569) to develop hyperpolarized 15N-labeled nicotinamide riboside as a magnetic resonance spectroscopy probe for monitoring NAD+ and NADH levels in vivo. The funded research addresses...
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $536,853 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development and validation of a comprehensive 7 Tesla MRI framework for simultaneous high-resolution mapping of brain iron and myelin in mesoscale brain structures. The project integrates three complementary...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Arlington $339,676 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop light-responsive osmium compounds as metallo-reagents for biomedical imaging and photoactivation. The project develops osmium-based...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $486,805 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop margination-mediated delivery and glutathione-triggered release mechanisms enabled by renal-clearable gold nanoparticles for fluorescence-guided surgery of brain metastases. The project addresses a clinical gap: current...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
- The National Institute of General Medical Sciences awarded the University of Texas at Dallas $1.928 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant investigating how cellular metabolism shapes embryonic development. The funded research integrates advanced imaging, genetic tools, and single-cell sequencing in the chordate model Ciona to examine how metabolic rewiring orchestrates gene regulatory networks during...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Texas Health Science Center at Houston $158,220 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of neutrophil-derived HIF1A signaling in hepatic ischemia/reperfusion injury. The research addresses mechanisms of graft dysfunction following liver transplantation, a leading cause of poor outcomes in end-stage liver...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $2,999,512 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2029. This award supports fundamental biomedical research investigating the regulation of mitochondrial health in mammalian livers, with the...
The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $138,813 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to support Dr. Mai Thuan Huynh's transition to independent investigator status in metabolism and molecular imaging research. The award funds design, synthesis, and validation of advanced carbon tracers to image gluconeogenesis, addressing the hypothesis that renal gluconeogenesis increases during type 2 diabetes progression and may rival or exceed hepatic glucose production. Specific Aim 1 focuses on development and hyperpolarization of cell-permeable [1,4-13C2]oxaloacetate derivatives to measure gluconeogenesis and TCA cycle fluxes in diabetic mouse liver and kidneys using hyperpolarized 13C magnetic resonance imaging. Specific Aim 2 employs [1-11C]lactate positron emission tomography to evaluate flux through the pyruvate carboxylase-pyruvate dehydrogenase branch point based on tracer retention kinetics. The award includes mentorship from Drs. Craig Malloy, Zoltan Kovacs, and Xiankai Sun, with additional guidance from Drs. Dean Sherry, Philipp Scherer, and Spencer Bowen. Performance occurs in Dallas, Texas, from September 1, 2026, through August 31, 2030. This is a project grant, a training and research award mechanism under the NIBIB program designed to support hypothesis- and technology-driven biomedical imaging research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $138.8k | 9/1/26 |