This $556,525 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program is funding the development, testing, and dissemination of advanced micro-LED optoelectrode platforms. The award recipient, the Regents of the University of Michigan, will design and optimize high-density micro-LED optoelectrodes in various configurations to enable...
This $299,896 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports the development of a novel modular bioluminescence imaging (BLI) platform called InVivoScan by In Vivo Analytics, Inc. The key products being developed include: A multi-aperture (MA) imaging method featuring a concentric mirror system and stray-light collimator to significantly boost BLI sensitivity and enable multi-view imaging and 3D...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,091,260.00 to the Regents of the University of Michigan to develop novel bispecific antibody (BAB) "immunocytokines" that can efficiently deliver the cytokine interleukin-2 (IL-2) to the central nervous system (CNS). The key objectives are to: 1)...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) supports the development of a compact, semiconductor-based Single-Molecule Assay (SIMOA) system for sensitive detection of low-abundance protein biomarkers. The $447,304 award will fund the integration of microfluidics, electronics, and sensing capabilities within a...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is supporting research to develop mitochondrial-targeting exosomes (MTEs) containing anti-inflammatory microRNAs (MTE-miRNAs) to treat neuroinflammation. The $469,500 award to Michigan Technological University aims to restore mitochondrial function, reduce oxidative stress,...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, Davis to develop a miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic manipulation of neural activity in freely-behaving mice. The project will integrate innovative beam forming techniques into a...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $359,995 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to Clemson University. The funding supports the development and validation of a novel X-ray visualized immunosensor (X-VIS) that can be attached to implanted medical devices to detect and monitor local infection biomarkers. The project aims to fabricate a...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is focused on developing an advanced interferometric diffuse optics (IDO) system to provide highly sensitive and quantitative measurements of cerebral blood flow. The $580,654 grant will fund the development of a 1064 nm IDO system that leverages "coherence...
This Project Grant award of $434,610 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports the development of light-triggered molecular tools critical for understanding the brain's neural network. The principal investigator, Dr. Nasri Nesnas of the Florida Institute of Technology, is collaborating with neuroscientists to design and use these tools to precisely manipulate calcium ion concentrations and enable temporal control of...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,337,953.41 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of Arizona to develop and disseminate an advanced 2-photon Bessel beam light sheet (2PBLS) microscopy instrument. This system will enable high-speed, sub-micron-resolution volumetric imaging in deep tissue, with simultaneous lifetime imaging using FRET sensors and...