This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will fund the development of machine learning-guided polymeric nanocarriers for intracellular delivery of ribonucleoproteins (RNPs). The $198,646 award to the Trustees of the Colorado School of Mines will support an interdisciplinary effort to engineer chaperone-mimetic polymers that can refold misfolded RNPs, improving the precision and efficiency of genome editing. The project will also leverage transfer learning to tailor the polymeric carriers for hard-to-expand hematopoietic stem and progenitor cells, which are key targets for RNP-based therapies. This work aims to alleviate the financial burdens associated with RNP therapeutics by developing an innovative, machine learning-driven approach to unlock the potential of polymeric nanocarriers for intracellular RNP delivery.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $198.6k | 4/15/25 |