This $325,000 project grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support the development and testing of a new class of programmable, non-viral gene therapy carriers and cargo known as virus-inspired DNA origami (VIDO) vectors and repair templates. The project aims to demonstrate that VIDO vectors can effectively encapsulate and co-deliver CRISPR-Cas9 gene editing agents and repair...
This $1,539,200 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports the development of an integrated technology platform to characterize the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides. The key products to be delivered include: A novel ionization technique called Capillary Vibrating Sharp-Edge Spray Ionization (CVSSI) that...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $275,773 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Dropletpharm Inc., a for-profit company. The grant supports Dropletpharm's development of microfluidic technologies to enable low-cost and distributed manufacturing of radiopharmaceuticals for clinical and research applications. Specifically, the project aims to expand...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Cornell University a $435,412 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The goal of this 2-year project is to develop a biomaterial-driven, immunosuppressive platform that enables the re-administration of engineered adeno-associated virus (AAV) gene delivery vectors while maintaining their transduction efficiency....
This federal Project Grant award, with ID R01EB037025, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The $540,524 award, effective March 1, 2025 through February 28, 2029, supports research and development of an enhanced RNA switch technology based on the T3H38 ribozyme. This technology aims to enable precise dose control...
This Project Grant award of $660,875 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop a high-throughput in vivo protein barcoding method to study the biochemical properties of protein variants. The key objectives are: Assessing the thermal stability of dihydrofolate reductase variants expressed in E. coli and fused to a tRNA modifying enzyme that attaches a unique RNA barcode to each variant. The barcodes allow pooled biochemical assays with...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will fund research to develop machine-learning guided polymer carriers for the delivery of ribonucleoproteins (RNPs) to hematopoietic stem and progenitor cells (HSPCs). The goal is to engineer chaperone-mimetic polymers that can refold RNPs into catalytically competent...
This $372,210 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop fluorescent nucleoside analogues and apply them to advance RNA-centered therapeutics. The key products and services to be delivered include: Creating modified antisense oligonucleotides (ASOs) and short interfering RNAs (siRNAs) incorporating fluorescent ribonucleosides to enable live-cell imaging of RNA...
The federal Project Grant award of $1,249,099, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports the development of a new class of bright, tunable, and biocompatible near-infrared (NIR-II) fluorescent biolabels for deep tissue molecular imaging. The University of California, Irvine (UC Irvine) will pioneer the use of DNA-stabilized silver nanoclusters (AgN-DNAs) that emit in the NIR-II spectral region, enabling...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is funding research to develop an enzyme-free, label-free quantitative microarray technology capable of detecting and quantifying small nucleic acid sequences, such as microRNA, at attomolar concentrations. The $432,834 award to the University of Nebraska aims to design a novel "binary probe" system and specialized opto-electrochemical...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, aims to develop a novel research tool for in vivo high-throughput screening of targeted nucleic acid delivery. The $851,000 grant, awarded on August 15, 2024, supports a collaborative effort between the Emmitte Group and the Kim Group to synthesize and validate deuterated peptoid-based barcodes as an inert, stable, and sensitive tracer for gene-encapsulated nanoparticles. The project will demonstrate the utility of this barcode technology for conducting efficient biodistribution studies of multiple nanoparticle formulations in healthy mice, thereby advancing the development and clinical translation of non-viral gene delivery vectors.