This $117,074 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research at Lehigh University to develop biomaterial-guided CRISPR gene editing delivery systems. The key objectives are to: Determine how peptide-based nanoparticle formulation and properties impact CRISPR ribonucleoprotein (RNP) uptake, activity, and functionality. Investigate how material charge and porosity control the temporal action of CRISPR...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $419,363 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the Trustees of the Colorado School of Mines, doing business as Colorado School of Mines. This 3-year grant, awarded on April 15, 2025, aims to develop machine learning-guided polymer discovery pipelines for intracellular delivery of ribonucleoproteins (RNPs). The project will engineer...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program, CFDA 47.049, provides $418,280 to the University of California, San Diego to develop new methods for attaching synthetic polymers to the surface of cells. The goal is to enable precise control over how cells interact with their external environment, which is important for advancing cell-based technologies like cell-based therapeutics, biosynthesis, and sensors. The project will focus on...
This Project Grant award, provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) program, supports research on a new class of materials called protein-like polymers (PLPs). The $170,954 award funds a collaborative research effort to study how these PLP materials can mimic the structure and function of proteins, enabling them to interact with and penetrate biological membranes and cells. The goal is to elucidate the mechanisms by which...
This Project Grant award of $421,781 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports the University of Chicago in developing advanced polymer materials with unprecedented mechanical properties and self-healing capabilities. The research aims to create an integrated database of adaptive polymer networks that are highly stretchable, resilient, and self-healing through the use of novel double-threaded slide-ring polymers and dynamic...
This $244,960 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will fund research at the University of Minnesota to develop new computational methods for discovering novel block polymer materials. The project aims to use generative artificial intelligence techniques to propose new block polymer structures, and then apply machine learning to identify the appropriate polymer chemistries and processing conditions to...
This Project Grant award of $600,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research by Professor Mahesh Lakshman of the City College of New York (CUNY) to develop novel chemical methods for modifying nucleosides, which are fundamental building blocks of DNA and RNA. The overarching goal is to obtain a fundamental understanding of chemical processes to achieve selective modifications of nucleosides, which have diverse...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $273,291 to the University of California, Santa Barbara to develop computational tools that combine machine learning and scientific computing for the exploration and prediction of polymer systems. The goal is to accelerate the discovery of new materials and provide a framework for computationally costly problems across various scientific domains. The research...
This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will enable research on a new class of "active polymers" that can respond to local energy fluctuations. The $495,000 award to the University of Massachusetts (UMass) will support the development of experimental methods to produce and study the mobility of these active polymers, with a focus on how energy injection at the molecular level impacts their behavior...
This Project Grant award of $150,620, provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports research by the Trustees of the Colorado School of Mines (CSM) to develop improved methods for delivering genome-editing proteins into cells. The goal is to use polymer-based delivery systems to more efficiently transport these proteins, which have the potential to treat genetic disorders and other diseases. The research aims to understand how the chemical properties of polymers affect their ability to bind and carry different genome-editing proteins, as well as their cell type preferences. The project will leverage machine learning and advanced polymer science to systematically explore the vast design space and identify optimal polymer formulations. The research outcomes are expected to advance basic biological research and improve public health by lowering the cost of deploying genome-editing technologies. The award also includes an educational plan to engage and prepare students from underrepresented backgrounds for careers in STEM and biomaterial design.