Project Grant R21EB034932
- Federal Grant Award Summary Purdue University received a $395,455 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2030. The award funds development of computational methods and deep learning-based approaches for biomolecular structural modeling of cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) data. The research addresses...
- Federal Project Grant Award Summary Purdue University received a $391,764 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective September 1, 2025, through August 31, 2028. The award funds the development of a coherent Doppler spectroscopy imaging system—referred to as a "cell radar speed gun"—designed to measure the velocity and movement patterns of...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the University of Missouri System $418,043 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for a two-year project grant running from August 1, 2025, through July 31, 2027. The project deliverables center on the design and development of a self-tunable messenger RNA (mRNA) circuit capable of sustained, precise regulation...
- Federal Project Grant Award Summary Purdue University received a $412,632 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective April 5, 2026, with completion targeted for February 28, 2031. The award supports a systematic evaluation of competition between double-stranded RNA binding proteins (dsRBPs), fundamental research aimed at understanding how these ubiquitous cellular proteins...
- Federal Project Grant Award Summary Purdue University received a $150,104 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on March 12, 2026, with a completion date of November 16, 2028. The grant supports fundamental research investigating the role of the CSOS2 protein in carboxysome assembly and regulation—protein-based micro-compartments found in cyanobacteria that enhance carbon...
- Federal Grant Award Summary Award Details: This $412,632 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University, effective August 1, 2025, with a completion date of July 31, 2030. Products and Services: The award funds research in biocatalytic synthesis of complex medicinal small molecules informed by artificial intelligence planning. The project addresses three...
- Federal Project Grant Award Summary Purdue University received a $150,000 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded September 1, 2025, with completion targeted for July 31, 2029. The project, titled "AI-Guided Intraoral Multimodal Active Sound Sensing for Advanced Pulmonary Function Characterization," develops a novel non-invasive respiratory monitoring system designed to address...
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Washington University a $598,134 Project Grant on August 5, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop sensing collimator technology for ultrasensitive Single Photon Emission Computed Tomography (SPECT) imaging of targeted radiopharmaceutical therapies. The four-year project, concluding...
- Federal Project Grant Award Summary Northeastern University received a $673,600 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective August 1, 2025, through July 31, 2028. The award supports development of programmable RNA-based sensors that detect integrated changes in both messenger RNA (mRNA) and microRNA (miRNA) to enable in...
- Federal Grant Award Summary George Mason University received a $535,416 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective August 1, 2025, through May 31, 2029. The award supports the development of a DNA-templated near-infrared-II (NIR-II) potassium reporting toolkit designed to enable noninvasive mapping of ionic activity in...
Purdue University received a $375,337 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period July 1, 2025 through June 30, 2027. The award funds development of fluorescence-detected photothermal infrared (F-PTIR) microscopy technology designed to track intracellular messenger RNA (mRNA) release from lipid nanoparticle (LNP) formulations in real-time with nanoscale spatial resolution. The primary deliverable is an advanced imaging tool that uses fluorescently labeled mRNA as a local temperature sensor to detect infrared absorption and generate chemical-selective spectroscopy data at resolutions below the optical diffraction limit. The research addresses critical gaps in understanding intracellular barriers to mRNA delivery, particularly the endosomal escape process that currently limits transfection efficiency to approximately 1-2% of administered doses. By enabling direct observation of LNP behavior and mRNA fate within live cells, this technology is expected to provide insights that improve therapeutic delivery of mRNA-based biologics and reduce patient-to-patient variability in treatment efficacy and side effects. The project aligns with NIBIB's mission to advance biomedical imaging and bioengineering technologies for improved disease detection, diagnosis, and treatment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $375.3k | 7/31/25 |