Project Grant 2519763
- This federal Project Grant award of $300,000.00, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), will fund a collaborative research effort to develop chimeric antigen receptor (CAR)-engineered extracellular vesicles (EVs) derived from induced pluripotent stem cell (iPSC)-derived neutrophils. The objective is to engineer these CAR-associated EVs to possess enhanced targeting ability to glioblastoma, an aggressive type of brain cancer. The research team at...
- This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
- This $600,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program aims to develop an innovative Optomagnetic Twisting Cytometry (OMTC) system to quantify the dynamic viscoelastic properties of 3D tissue samples. The project will construct an optical scanning system to enable simultaneous measurements of hundreds of thousands of microparticles within a large field-of-view, advancing the understanding of the mechanical properties of live...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $574,808 to Duke University over 5 years to study the origins of cellular heterogeneity in T-cell therapies. The research leverages cutting-edge technologies like spatial proteomic multiplexed imaging, in vitro cell tracking, and engineered biomaterial artificial antigen-presenting cells to better understand how single-cell variability arises during the growth and modification of...
- The National Science Foundation (NSF) awarded a $353,843 Project Grant under CFDA Program 47.041 (Engineering) to the University of Washington to develop a unique biosensing system in E. coli bacteria to recognize extracellular cancer antigens and respond with a toxic, immunostimulatory payload. This 3-year project from March 2025 to February 2028 aims to create programmable and dynamically-responsive bacterial therapeutics as a low-cost alternative to engineered human T cell therapies for...
- This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new optical microscopy technology called "Space-Time-Pulsed Engineered-Excitation for Diffraction-Free Imaging (SPEEDI)." The technology utilizes exotic space-time wave packets to enable high-resolution fluorescence imaging of deep brain tissue without the light scrambling issues of conventional microscopy. The research aims to advance imaging...
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and...
- This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $632,300 to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at subcellular resolution. The goal is to advance the application of spatial biology in cancer research by visualizing...
This $391,764 federal Project Grant awarded by the National Science Foundation (CFDA 47.041 - Engineering) to Purdue University will fund the development of a laser-based "cell radar speed gun" to measure the speed of cancer cells crawling through living tissue and the speed of immune cells patrolling tumors. The goal is to use this biodynamic imaging technology to assess the effectiveness of cancer immunotherapies for individual patients. The award will also extend biodynamic imaging capabilities to measure a broader range of cellular functions like metastatic motion and fast vesicle transport. The research aims to establish biodynamic imaging as a reliable method for rapidly selecting personalized cancer treatments, especially when drug resistance is a barrier to effective treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $391.8k | 8/15/25 |