Project Grant R56DK142828
- This federal Project Grant award of $154,860 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research on the mechanisms of clonal competition in age-related clonal hematopoiesis. The grant, awarded to The Children's Hospital Corporation (Boston Children's Hospital), aims to investigate factors that drive the expansion of "super-competitor" clones bearing DNMT3A mutations, which are associated with increased risk of hematologic diseases...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $465,155 to Brigham & Women's Hospital Inc. to conduct research on the role of the SRCAP gene in therapy-related clonal hematopoiesis and the development of therapy-related myeloid neoplasms. The award supports the development of a novel conditional mouse model to study the impact...
- This federal Project Grant award of $242,048 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Versiti Wisconsin, Inc. to investigate DNA damage responses and potential chromosomal abnormalities in hematopoietic stem and progenitor cells following genome editing. The goal is to enhance the understanding of genotoxicities and...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $133,333 Project Grant to Yale University to study the mechanisms underlying the myeloid bias in aged hematopoietic stem and progenitor cells (HSPCs). The research aims to correct this myeloid bias by preventing the turnover of the linker histone H1.0, which could have implications for addressing diverse...
- This federal Project Grant award of $661,694, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to enhance the understanding of the role of the FANCD2 protein in kidney development, repair, and chronic kidney disease. The award supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital, to investigate FANCD2's...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $143,968.00 to support research on early detection and treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). The research aims to examine whether markers of endothelial injury and complement overactivation can predict HSCT-TMA, as well...
- This Project Grant award, valued at $172,060, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research conducted by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to understand the mechanism of unfolded protein response (UPR) loss in human non-alcoholic steatohepatitis (NASH) and how the UPR...
- This federal Project Grant award for $412,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training program, supports a research program to improve the interpretation of rare genetic variants. The awardee, The General Hospital Corporation doing business as Massachusetts General Hospital (MGH), will use state-of-the-art computational methods to enhance existing annotation tools for predicting the impact of...
- This federal Project Grant award of $150,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The grant supports research by Mayo Clinic to study the clinical significance of somatic mosaic states in the context of short telomeres, which are associated with Telomere Biology Disorders (TBD). Specifically, the research aims to create and characterize a new...
- This federal Project Grant award of $560,100 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate how environmental exposures, such as industrial pollution and catastrophic events, lead to hematopoietic stem cell dysfunction and the progression of clonal hematopoiesis. The project, awarded to the Albert Einstein College of Medicine in Bronx, NY, will...
This federal Project Grant award of $133,328 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to dissect the roles of the PPM1D and TP53 genes in hematopoietic stem cells and clonal hematopoiesis. The research aims to understand how mutations in these genes contribute to the acquisition and selection of recurrent, somatic mutations in hematopoietic stem cells, which is a significant risk factor for myeloid neoplasia and mortality. The award has a project period from September 20, 2025 to September 19, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.3k | 9/16/25 |