This $1,123,357 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Childrens Hospital Medical Center in Cincinnati, Ohio to define the specialized vascular microenvironments in bone marrow and how they regulate blood cell production under homeostatic, inflammatory, and regenerative conditions. The 7-year research program has three complementary objectives: 1) Dissect the function of specialized bone marrow microenvironments that serve as niches for major blood cell lineages; 2) Determine how specialized sinusoids sense inflammation and orchestrate the hematopoietic response; and 3) Discover how stem cell and progenitor cell engraftment and hematopoietic recovery are regulated by specialized bone marrow microenvironments after transplantation. This work aims to provide a new framework for understanding blood cell differentiation, disease mechanisms, and developing ex vivo blood cell production systems.
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