Project Grant R21DK142082

Award Date 9/6/24
Completion Date 8/31/25
Dollars Obligated $401K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Detroit, MI 48202, USA
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This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund the development of genetically encoded chloride sensors to measure sodium-chloride transport in the kidneys of live mice.

The $400,820 award will enable researchers at Wayne State University to generate transgenic mouse models expressing chloride-sensing probes. This will allow them to use two-photon microscopy to measure sodium-chloride reabsorption in the thick ascending limb and distal convoluted tubule of the nephron in live animals. The project aims to create new tools to study kidney salt transport and spur the development of additional ion sensors for live animal research. The award period is from September 6, 2024 to August 31, 2025.

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