This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $115,500 to Wayne State University to conduct research on the molecular mechanisms by which high-salt diets regulate the activity of the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the kidney. The research aims to identify novel E3 ubiquitin...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,950 to The Research Foundation For The State University Of New York to develop a microfluidic device that models the complex structure and selective filtration function of the kidney's glomerulus and Bowman's capsule. This "Glomerular-Bowman's Capsule System on a Chip" will...
This federal Project Grant award of $293,128 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research will support research by The Johns Hopkins University to uncover the role of the G-protein coupled receptor GPR39 in kidney physiology. The research aims to examine the mechanisms by which GPR39 activation influences water reabsorption in the kidney and determine the physiologic function of...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $934,946 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Virginia Commonwealth University (VCU). The grant supports research to investigate the role of the acid ceramidase-sphingosine-1-phosphate (AC-S1P) pathway in the kidney's regulation of sodium excretion and its potential contribution to salt-sensitive hypertension. Specifically, the research...
This $531,999 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), will support research at Washington University on the role of alternative splicing in the progression of diabetic kidney disease (DKD). The research aims to: 1) Define and validate the spectrum of alternative splicing in DKD and the impact of sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment using long-read RNA sequencing; 2) Test the hypothesis...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,986 to the University of Pittsburgh to investigate the role of BK gamma subunits in regulating potassium secretion in the kidney. The award supports a 5-year research project focused on understanding how the BKγ2 subunit, which is highly expressed in intercalated cells, is...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding the development and validation of an allysine-targeted positron emission tomography (PET) probe to noninvasively quantify renal fibrosis. The $1,447,749 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) will support additional IND-enabling...