This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,472,604.00 to Childrens Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate the mechanisms driving cyst induction and growth in autosomal dominant polycystic kidney disease (ADPKD). The project aims to study how a second somatic mutation in...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the physiological functions of the polycystin-1 (PC1) protein and how its dysfunction leads to autosomal dominant polycystic kidney disease (ADPKD). Specifically, the $640,001 award to Yale University will explore whether a short fragment of the PC1 protein...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the CDKN1A (p21) gene in the development and progression of polycystic kidney disease (PKD). The $587,212 award, granted to the University of Alabama at Birmingham (UAB), aims to determine whether abnormal regulation of p21 is part of an...
This federal Project Grant award of $2,029,830.00, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the structures and channel properties of various polycystin protein complexes. The goal is to clarify the mechanistic roles of these disease-associated proteins, understand the impact of disease-associated mutations, and inform future...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $135,582 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Oklahoma Health Sciences Center to construct a single-cell atlas of mouse and human cells in autosomal dominant polycystic kidney disease (ADPKD). The project aims to understand how molecular and cellular pathways found in ADPKD patients correlate to mouse models, and to identify inter-...
This $492,329 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the FBW7 gene in the development of cystic kidney diseases. The project aims to enhance understanding of the cellular mechanisms driving cyst formation, fibrosis, and tubular degeneration, with the goal of identifying new therapeutic targets...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $225,304 to Northwestern University for research on polycystin proteins and their role in autosomal dominant polycystic kidney disease (ADPKD). The primary goals of this project are to: 1) Characterize the functional consequences of ADPKD disease-causing variants in the PKD2 gene using...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $223,918 to the University of Oklahoma Health Sciences Center to research ways to slow the progression of autosomal dominant polycystic kidney disease (ADPKD). The research aims to understand how kidney resident macrophages (KRM) contribute to ADPKD progression and explore methods...
This $728,513 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to develop and validate renal quantitative susceptibility mapping (QSM) as a novel biomarker for detecting and quantifying hemorrhagic cysts in patients with autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: 1) develop robust and accurate renal...
This $142,902 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to uncover the mechanism by which the regulatory GTPase ARL13B drives polycystic kidney disease (PKD) pathogenesis. The research, led by Dr. Van Sciver at Emory University, will biochemically and genetically dissect ARL13B's interaction with three effector proteins - CDK1, ARL3,...