Project Grant R01DK139336

Award Date 1/20/25
Completion Date 11/30/29
Dollars Obligated $729K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
미국 뉴욕
Similar Awards
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the mechanisms of cyst induction and growth in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The $1,472,604 award, spanning from August 2024 to May 2029, will utilize mouse models and organ cultures to study how secondary genetic mutations and environmental...
This $504,621 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to investigate the role of intracellular cholesterol biosynthesis in regulating the progression of autosomal dominant polycystic kidney disease (ADPKD). The research team at the University of Texas Southwestern Medical Center will conduct studies to determine if...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $640,001.00 to Yale University to conduct research on the mechanisms and potential therapeutic applications of polycystin-1 (PC1) protein cleavage in autosomal dominant polycystic kidney disease (ADPKD). The research aims to: 1) determine whether expression of the final 200...
This $199,922 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA Program 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research", supports research to define the role of iron homeostasis in the progression of chronic kidney disease (CKD) at Weill Medical College of Cornell University. The research aims to elucidate the fundamental mechanisms of intracellular iron regulation in the kidney that contribute to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,476.00 to support research on targeting kidney resident macrophage niche filling to slow the progression of autosomal dominant polycystic kidney disease (ADPKD). The key objective is to study the mechanism of kidney resident macrophage niche repopulation after temporary depletion and...
This federal Project Grant award of $225,304.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to characterize the functional consequences of autosomal dominant polycystic kidney disease (ADPKD) disease-causing variants. The grant recipient, Northwestern University, will implement a novel synthetic biology approach to investigate the membrane integration...
The federal Project Grant award R21DK140693, totaling $135,582.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of this grant is to construct mouse and human single-cell atlases in autosomal dominant polycystic kidney disease (ADPKD) to better understand the molecular and cellular pathways in ADPKD patients and how they correlate to mouse...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to utilize gadolinium-free kidney functional magnetic resonance imaging (fMRI) to identify biomarkers that can non-invasively detect chronic kidney disease (CKD) subtypes and predict disease progression. The $1,695,959 award will support testing the associations between kidney...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $152,453 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Boston Medical Center Corporation (BMC) to develop and validate an automated assessment of kidney vascular pathology and risk of adverse cardiovascular events. The grant will also integrate digital pathology, clinical parameters, and kidney disease proteomics data into a predictive...
The University of Pittsburgh received a $198,750 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a rapid, quantitative platform using yeast to classify how approximately 70 identified mutations in the polycystin-1 (PC1) protein disrupt channel activity with PC2. This research aims to provide new reagents and assays to the scientific and PKD (polycystic kidney disease) community to study the molecular defects of PC1 mutants. The...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $728,513 to Weill Medical College of Cornell University to develop and validate the use of renal quantitative susceptibility mapping (QSM) for detecting hemorrhagic cysts as a prognostic biomarker in autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: 1) develop robust and accurate renal QSM techniques, 2) validate renal QSM using biochemical and histological data from kidney explants, and 3) validate renal QSM for assessing the risk of glomerular filtration rate decline in ADPKD patients. This longitudinal study aims to demonstrate that QSM can reliably identify hemorrhagic cysts, enabling improved risk stratification and targeting of ADPKD therapies. The award period runs from January 20, 2025 to November 30, 2029.

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