Project Grant R21DE036066
- The National Institute of Dental and Craniofacial Research awarded $597,769 to the Trustees of Columbia University in the City of New York on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, a Project Grant). The award funds development of an engineered hydrogel-patient-derived organoid platform with tunable viscoelastic properties designed to model oral epithelial dysplasia and recapitulate the biomechanics of dysplasia and oral squamous cell carcinoma...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research, within the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $320,660 on July 9, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop anionic nanohybrid aggregate formulations for early childhood caries prevention. The project addresses early childhood caries affecting approximately 25 percent of American preschool children, particularly those of...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health within the Department of Health and Human Services, awarded $435,875 to Indiana University Indianapolis on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate oxylipin-mediated biofilm colonization in peri-implant disease. The research explores the role of oxylipins in regulating bacterial biofilm formation around dental implants. The study aims...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded The Washington University $427,625 on February 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to develop and evaluate radiation-guided theranostic agents for detecting and monitoring response to oral cancer treatment. The research leverages radiation-inducible antigens, specifically...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded The University of Chicago $133,239 on April 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and deliver a research education program called Cultivating Researchers in Oral and Systemic Health Studies (CROSS). The program trains undergraduate students enrolled in colleges across the Chicago area in cross-disciplinary clinical research that integrates oral health, medicine, and the social...
- The National Institute of Dental and Craniofacial Research awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $539,217 on September 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the microbiology of dentin invasion in dental caries. The project addresses how cariogenic microbes invade dentin—the tooth structure beneath enamel—and reach the pulp, causing toothaches, periapical inflammation, abscess, and systemic...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institutes of Health National Institute of Dental and Craniofacial Research awarded The Trustees Of The University Of Pennsylvania $521,273 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research into dendritic cell and T cell dysregulation in periodontitis associated with poorly controlled diabetes. The project examines how hyperglycemia reprograms dendritic cells and T cells through epigenetic mechanisms, activating...
The National Institute of Dental and Craniofacial Research, within the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $471,123 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) for the AHEAD project (Adolescent Health and the Early-Life Dietary Exposome: Developing a Metabolomics-Based Index of Healthy Eating to Predict Children's Health Trajectories). The project characterizes the quality and cariogenicity of children's diets and develops metabolomics-based indices of healthy and unhealthy eating to explore their ability to predict phenotypic health outcomes in adolescence. The research leverages existing data from the Columbia Center for Children's Environmental Health, part of the NIH-funded Environmental Influences on Child Health Outcomes (ECHO) Collaborative, including dietary, biospecimen, anthropometric, and medical and dental records to identify common risk and protective factors underlying oral and systemic diseases and improve understanding of how early-life dietary and environmental exposures determine children's health trajectories. Work is performed in New York, New York (10032). The project period runs from August 1, 2026, through July 31, 2028. This is a Project Grant award under the assistance type classification.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.1k | 7/28/26 |