Project Grant R21DE036033
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a $135,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective August 1, 2025, through July 31, 2027. This research initiative addresses the clinical need for non-toxic therapeutic approaches to treat apical periodontitis (AP) and pulpal necrosis in permanent teeth across all developmental stages. The project...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $219,660 Project Grant to the Regents of the University of Michigan, effective January 1, 2029, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative, titled "Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer," delivers preclinical research services focused on understanding the immunological...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a $584,420 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) effective May 1, 2026, through April 30, 2030, to conduct research on the cellular and genetic mechanisms underlying osteonecrosis of the jaw (ONJ). This condition, characterized by exposed and necrotic bone in the maxillofacial region, primarily affects cancer patients...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a Project Grant totaling $527,732 under the Oral Diseases and Disorders Research program (CFDA 93.121), with an award date of February 15, 2026, and completion date of January 31, 2031. This research initiative investigates the role of tissue homeostasis in Sjögren's Disease (SJD), a chronic autoimmune condition affecting the salivary and...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
- Summary The University of Michigan received a $385,184 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on September 11, 2025, with completion targeted for March 31, 2027. This research initiative will develop noninvasive diagnostic techniques to improve detection and characterization of periodontal inflammation, addressing a critical clinical need affecting approximately 42% of...
- Federal Grant Award Summary The University of Washington received a $622,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 1, 2025, through July 31, 2027. The project, "Characterizing the Microbial and Inflammatory State Within Distant Clinically Healthy Tissues in Patients with Active Periodontal Disease," will deliver single-cell RNA sequencing...
- Federal Grant Award Summary The University of Michigan received a $312,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded March 1, 2026, with completion targeted for February 28, 2028. This research initiative aims to elucidate the role of retinoic acid (RA) signaling in ameloblast differentiation and enamel formation. The project will integrate single-cell RNA sequencing...
- Federal Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $568,759 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective May 1, 2026 through April 30, 2031. This five-year research initiative investigates the pathogenic mechanisms underlying periodontitis, a chronic inflammatory disease affecting the tissues supporting teeth...
- Federal Grant Award Summary Baylor College of Medicine received a $453,797 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 5, 2026, with completion targeted for June 4, 2028. The grant supports fundamental research investigating the structures and functions of natural products in periodontal disease, specifically examining novel biosynthetic gene clusters identified in...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a $429,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective June 5, 2026, with completion targeted for June 8, 2028. The award funds research investigating the effects of recurrent periodontitis on hematopoietic stem cell (HSC) function and systemic health outcomes. The research will establish a chronic periodontitis model to evaluate long-term impacts on HSCs while accounting for sex-dependent differences and distinguishing between local and systemic effects. The research addresses the mechanistic relationship between periodontitis—a common oral inflammatory condition—and systemic comorbidities including cardiovascular disease, rheumatoid arthritis, and type 2 diabetes. By examining how recurrent inflammatory episodes affect HSC function and clonal complexity, the study aims to clarify whether periodontitis-induced HSC decline contributes to age-related hematologic diseases such as clonal hematopoiesis and myeloid leukemias. The work will be conducted at the University of Michigan's Ann Arbor campus and represents a fundamental research contribution to understanding the oral-systemic health nexus.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 6/10/26 |