Project Grant R21DE035939
- Federal Project Grant Award Summary Virginia Commonwealth University received a $310,500 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 15, 2026, with completion scheduled for June 14, 2027. The grant funds mechanistic research investigating the role of nuclear bone morphogenetic protein 2 (NBMP2) in macrophage-mediated periodontal regeneration and bone repair. The project...
- Federal Project Grant Award Summary Virginia Commonwealth University received an $854,416 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 12, 2025, with completion targeted for May 31, 2030. The award funds research into immunostimulatory microbial pattern recognition as a therapeutic strategy to improve treatment outcomes for head and neck squamous cell carcinoma...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $435,875 to Indiana University Indianapolis through its Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2026, for a two-year project concluding July 14, 2028. The project, titled "PERIOX - Peri Implant Oxylipin Mediated Biofilm Colonization," will conduct exploratory research to elucidate the mechanisms by which bacterial biofilms form and persist around...
- Federal Project Grant Award Summary Virginia Commonwealth University received a $310,500 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on July 15, 2025, with completion scheduled for July 14, 2027. The grant supports comparative experimental evolution research examining gene essentiality differences between two oral streptococcal species: Streptococcus sanguinis and S. mutans....
- Federal Grant Award Summary The University of Pittsburgh received $679,631 in Project Grant funding from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded February 15, 2026, with a completion date of January 31, 2031. This award supports research to develop and evaluate novel microparticle-based drug delivery systems for treating peri-implantitis (PI), a common inflammatory condition affecting...
- Federal Project Grant Award Summary Virginia Commonwealth University received $135,225 in federal funding from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) for a two-year project awarded August 4, 2026, with completion targeted for August 3, 2028. The award supports basic and translational research exploring the role of FOSL1 (FOS-Like Antigen-1) protein in mediating liquid-liquid phase separation (LLPS)...
- Federal Grant Award Summary Old Dominion University Research Foundation received a $583,826 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 14, 2025, through August 13, 2028. The grant funds research to develop pre-vascularization strategies for an integrated three-dimensional human osteo-mucosal model, building upon the awardee's previously completed NIH-funded work...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $540,629 to the University of Massachusetts Lowell on August 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating human oral host-pathogen interactions and dysbiosis modulation. The project, scheduled for completion by August 14, 2027, focuses on developing and validating an immunocompetent three-dimensional (3D) in vitro model...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $568,759 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) effective May 1, 2026, through April 30, 2031, to conduct basic research on pathogen synergy and immune subversion in periodontal disease. The research deliverables include scientific investigations of how two gram-negative anaerobic...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
Virginia Commonwealth University received a $446,611 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded July 7, 2026, with completion scheduled for July 6, 2028. The research project, "Mapping and Modulating Endothelial Dysfunction in Peri-Implantitis," delivers scientific investigation into the vascular mechanisms underlying peri-implantitis, a chronic inflammatory condition affecting approximately 20% of dental implant recipients. The project outputs include development of a spatially-resolved, multimodal atlas of peri-implantitis vasculopathy utilizing advanced technologies such as Xenium spatial transcriptomics, CODEX proteomics, and artificial intelligence analysis tools to characterize CD38 vascular endothelial cells and identify therapeutic targets. The research deliverables encompass functional assessments of endothelial cells isolated from peri-implantitis lesions and evaluation of pharmacologic interventions targeting NAD-dependent endothelial dysfunction. By addressing the disease mechanisms absent in periodontal disease and proposing reversible endothelial dysfunction as a druggable driver of implant-associated inflammation, this project contributes fundamental knowledge and potential diagnostic and therapeutic advances to improve clinical outcomes for implant recipients and reduce the clinical and economic burden of peri-implantitis in the aging U.S. population.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.6k | 7/9/26 |