Project Grant R21DE035696
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant totaling $310,615 (awarded March 10, 2025, with completion targeted for February 28, 2027) under the Oral Diseases and Disorders Research program (CFDA 93.121). The research initiative, titled "Nutritional Niches Within Supragingival Biofilms," addresses fundamental mechanisms of dental caries development by investigating microbial...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research awarded a $693,179 Project Grant to The Ohio State University on August 11, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a multistage mixed-methods research study examining Silver Diamine Fluoride (SDF) and Medicaid policy impacts on pediatric oral health. The project, which extends through May 31, 2030, will analyze national Medicaid data and conduct...
- Federal Project Grant Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a $645,988 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) on August 13, 2025, for research titled "Bacteriophages in Dental Caries: Roles and Potential as a Therapy." The two-year project, concluding August 12, 2027, will deliver comprehensive research services investigating the composition, abundance, and role of bacteriophages...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Maryland, Baltimore a $155,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period June 1, 2025 through May 31, 2027. This research project investigates the roles of ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) and ATP (adenosine triphosphate) metabolism in cementogenesis—the biological process of cementum...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $442,750 Project Grant, effective August 14, 2025, through August 13, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports the development and validation of a pathomimetic gingiva-on-a-chip platform designed to assess microbiota-directed anti-inflammatory...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pittsburgh a Project Grant of $454,002 under the Oral Diseases and Disorders Research program (CFDA 93.121) for research examining the dichotomy of phosphate actions in periodontal health. The award, effective September 15, 2025 through September 14, 2027, funds basic and translational research investigating how dietary phosphate availability influences periodontal tissue...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. received a $762,432 Project Grant from the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121) effective June 1, 2025, with a completion date of March 31, 2030. The award funds research into the role of the CD73 enzyme (ecto-5'-nucleotidase) in periodontal disease pathogenesis, specifically investigating how CD73 deficiency contributes to...
- Federal Project Grant Award Summary The Ohio State University received a $315,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded July 15, 2025, with completion expected by July 14, 2027. This research initiative focuses on developing novel antibody therapeutics targeting human papillomavirus (HPV) oncoproteins E6 and E7 to treat HPV-positive head and neck cancer (HNC). The project...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. received a Project Grant award of $385,116 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 22, 2025, with a completion date of May 31, 2030. The award funds research investigating senescent periodontal ligament cells as a therapeutic target for age-associated periodontitis. The project will examine whether...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. received a $645,009 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period June 15, 2025 through June 14, 2027. The award funds research investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of osteocyte-bacteria interactions mediated by the NOD1...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant totaling $469,207 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period of February 1, 2026 through January 31, 2028. The award supports research into pharmacological inhibition of Ectonucleotide Pyrophosphatase Phosphodiesterase 1 (ENPP1) to promote cementum regeneration and restore periodontal function. The research initiative addresses critical gaps in knowledge regarding cementum formation and regeneration through a comprehensive research portfolio encompassing human disorder analysis, genetically engineered mouse model studies, and in vitro cellular investigations. The primary deliverables under this grant include scientific findings and therapeutic development focused on modulating inorganic pyrophosphate (PPI) levels to enhance cementum growth and periodontal attachment, with potential applications to hypophosphatasia (HPP) treatment and broader periodontal disease management. This research represents an alternative pharmacological approach to enzyme replacement therapy and seeks to advance prevention and treatment strategies for periodontal diseases, among the most prevalent health conditions globally. The research will be conducted at The Ohio State University's Columbus, Ohio facility through its Office of Sponsored Programs Division.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $469.2k | 1/27/26 |