Project Grant R21DE035609
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded $870,334 to The Research Foundation for the State University of New York (RF SUNY) under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period August 1, 2025, through July 31, 2027. This Project Grant supports the development of an early tooth organoid model utilizing human induced pluripotent stem cells (iPSCs) to address critical gaps in understanding early tooth development...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded Icahn School of Medicine at Mount Sinai a $714,711 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) effective July 1, 2025 through March 31, 2030. This award supports research investigating mechanisms of salivary epithelium-specific expansion following radiation exposure. The research aims to identify selective pathways that can protect or regenerate salivary gland function without...
- Federal Grant Award Summary Rutgers The State University of New Jersey received a $498,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective September 1, 2025, through August 31, 2028. The grant funds research to advance understanding of cell fate determination processes in salivary gland development, specifically addressing mechanisms underlying differentiation of distinct...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $104,506 to The Research Foundation for the State University of New York through its Oral Diseases and Disorders Research program (CFDA 93.121) on March 5, 2025, to support single-cell profiling research on follistatin (FST) in oral squamous cell carcinoma (OSCC). The project, which extends through December 31, 2027, focuses on investigating how FST functions as a potential driver of OSCC by...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $100,676 Project Grant awarded December 1, 2025, through the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research on tissue-resident macrophages (TRMs) during salivary gland morphogenesis. The grant funds basic research designed to elucidate the functional role of TRMs in salivary gland development and to...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Delaware a Project Grant of $315,289 under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2025, with a completion date of July 14, 2027. This R03 grant funds basic research investigating the role of the SIX1 transcription factor in neural crest cell fate decisions within the mouse mandibular arch at single-cell resolution. The research addresses a...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $320,200 to The Research Foundation for the State University of New York on July 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support a two-year Project Grant investigating gene regulatory mechanisms of MLL4 (Mixed-Lineage Leukemia 4) in tooth enamel development. The research addresses the molecular and epigenetic mechanisms underlying amelogenesis (enamel...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Arizona a $644,970 Project Grant effective July 1, 2025, through June 30, 2030, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative addresses radiation-induced salivary gland dysfunction (xerostomia) in head and neck cancer patients, a chronic condition affecting over 73% of radiotherapy recipients. The research will develop a kinetic...
- This $628,965 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to elucidate how immune cells, specifically tissue-resident macrophages, regulate the development and differentiation of salivary gland epithelial cells. The research project, conducted at the Icahn School of Medicine at Mount Sinai, leverages expertise in salivary gland biology and niche-epithelial...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a Project Grant totaling $503,648 on June 13, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support basic research investigating transcriptional mechanisms governing mandibular ectoderm development. The research project, scheduled for completion by March 31, 2030, will examine how interactions between domain-specific transcription factors...
The National Institute of Dental and Craniofacial Research awarded $440,275 under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Research Foundation for the State University of New York to support a two-year project (February 1, 2026 – January 31, 2028) investigating transcriptional regulatory mechanisms of salivary gland regeneration. The project employs a systems biology approach utilizing a SIX1 conditional knockout mouse model to elucidate how the SIX1 transcription factor governs stem and progenitor cell activity during gland regeneration. Research activities include single-cell RNA-sequencing analysis to assess cellular identities and fate trajectories within the three-dimensional salivary gland ecosystem, as well as mechanistic investigations of how SIX1 functions as a pioneer factor to modulate the epigenome and direct gene expression programs necessary for specialized cell population differentiation. The deliverables from this project are expected to advance fundamental understanding of salivary gland biology and the molecular mechanisms underlying cellular regeneration by examining SIX1-driven gene and signaling regulatory networks in the context of epigenomic dynamics and injury-induced regeneration. Findings from this research may inform future therapeutic strategies for salivary gland dysfunction and regenerative medicine approaches. The work will be conducted at the University at Buffalo location in Buffalo, New York.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.3k | 1/29/26 |