Project Grant R21DE035319

Award Date 8/1/25
Completion Date 7/31/27
Dollars Obligated $196K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This federal Project Grant award of $1,386,899.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant aims to define how Sjögren's disease endotypes modify the immunobiology of salivary gland mesenchymal stromal cells, comparing mouse and human models. The research will use JAK inhibitors as immunopharmacological probes to determine the signaling pathways driving maladaptive mouse...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $248,750.00 to the ADA Forsyth Institute, Inc. (The Forsyth Institute) to investigate the role of cellular senescence in salivary gland dysfunction associated with Sjögren's syndrome. The research aims to determine the impact of cellular senescence on Sjögren's syndrome-related xerostomia (dry mouth) and...
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This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, is providing $429,000 to the University of South Alabama to conduct research on targeting phosphodiesterase 4 (PDE4) enzymes as a potential therapeutic approach for alleviating xerostomia (dry mouth) in Sjögren's syndrome. The research aims to evaluate the therapeutic benefits of selectively inhibiting specific PDE4 subtypes,...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $628,965.00 to the Icahn School of Medicine at Mount Sinai over a 5-year period from May 1, 2025 to April 30, 2030. The funding supports research to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland development and differentiation. The...
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This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop microphysiological systems (MPSs) that can recapitulate the complex pathogenesis of Sjogren's disease (SjD), a systemic autoimmune condition affecting the salivary glands.

The $196,459 award, effective from August 1, 2025 to July 31, 2027, will support research to investigate how collagen density and the presence of fibroblasts in the microenvironment impact epithelial cell and lymphocyte behavior in SjD. The goal is to create more physiologically relevant MPS models for future therapeutic testing. The research will be conducted by the University of Wisconsin System, leveraging expertise in SjD, salivary gland biology, MPS technologies, and advanced spatial genomics approaches.

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