Project Grant R21DE033826
Award Date
9/18/24
Completion Date
8/31/26
Dollars Obligated
$429K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
Similar Awards
This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under CFDA program 93.121 Oral Diseases and Disorders Research, provides $409,403 to Branchpoint Biosciences Inc. for the development of a comprehensive qPCR-based oral microbiome profiling platform. The objectives are to: (1) determine key oral microbial targets by analyzing public metagenomic data, and (2) design and validate qPCR assays to accurately detect and quantify those targets....
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $704,206 to Oregon Health & Science University (OHSU) to develop an "organ on-a-chip" model of oral cancer and bone invasion. The goal is to systematically manipulate, characterize, and validate tissue microenvironment variables linked to oral squamous cell carcinoma (OSCC) invasion into bone, elucidate...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
This Project Grant award, with a total funding amount of $234,000.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this project is to characterize the natural competence ability of oral Prevotella species and develop a genetic toolbox for detailed genetic studies of these bacteria. Specifically, the research aims to break the genetic tractability barrier within...
This Project Grant award of $156,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to determine the sex-specific differences in the immune microenvironment of head and neck squamous cell carcinoma (HNSCC). The research aims to 1) characterize sex-specific myeloid cell differences and activities in HNSCC tumor models, 2) investigate the impact of depleting neutrophils on...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $483,360 to the University of California, San Diego (UCSD) to conduct research aimed at identifying new precision therapies for oral cancer. The key focus is to exploit vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry to disrupt immune evasive mechanisms and enhance the activity of anti-PD-1...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $164,322 to the Regents of the University of Michigan to investigate the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. The researchers will utilize a preclinical mouse model to study the transition from oral epithelial dysplasia to head and neck squamous cell carcinoma, with a focus on...
This $612,048 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the role of the lysyl oxidase propeptide (LOX-PP) in regulating macrophage phenotypes and their impact on oral squamous cell carcinoma (OSCC) tumor suppression. The research aims to characterize the differential effects of wildtype versus variant LOX-PP on macrophage activation,...
This Project Grant award of $198,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a research study at The Pennsylvania State University (Penn State) to examine how one's background and socioeconomic factors shape oral microbial diversity and determine the extent to which these microbes contribute to oral health differences in the United States. The study will utilize 16S ribosomal...