This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will fund research to define oral squamous cell carcinoma (OSCC)-associated microbiome and metabolome signatures and determine if microbiota transfer from OSCC patients to mouse models promotes tumorigenesis. The $234,000 award to the University of Colorado-Denver will extend previous studies on the role of the human...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,564,226 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Virginia Commonwealth University (VCU) to investigate the role of FOSL1 super-enhancers in cisplatin-enriched cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). The key objectives are to: 1) examine the mechanism by which FOSL1 super-enhancers determine the functional properties of cisplatin-enriched CSCs, and...
The federal Project Grant award R01DE033797, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine if targeting the MARCHF8-autophagy pathway can remodel the tumor microenvironment and activate antitumor immunity in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC). The $642,488 award, with a project period from June 2025 to March 2030,...
This Project Grant award, totaling $390,000.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The primary objective is to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). Key products and services to be delivered include: Optimizing a high-throughput, single-cell co-culture system...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $245,504 to the University of North Carolina at Chapel Hill. The project aims to explore a novel approach for targeting the stress-specific function of the replication protein A (RPA) complex to enhance treatment responses in oral squamous cell carcinoma (OSCC). Key research activities include developing...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $808,264 to The Medical University of South Carolina to conduct research on the mechanisms of filopodia-mediated intracellular delivery of small interfering RNAs (siRNAs) via peptide carriers. The goal is to elucidate the mechanisms underlying filopodia-directed cell entry of the RD3AD-siRNA complex in...
This $659,936 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support a comprehensive study on racial disparities in oral cavity squamous cell carcinoma (OSCC) outcomes. The University of Maryland, Baltimore will conduct multi-scale analyses to evaluate biological, imaging, and socioeconomic factors driving survival differences between African American and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,805,385 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oregon Health & Science University (OHSU). The grant aims to define the T cell-based mechanisms underlying oral mucosal immune-related adverse events (irAEs) caused by anti-PD-1 cancer immunotherapy, with the goal of developing strategies to mitigate these side effects. The research will utilize human samples, mouse...
The federal Project Grant award of $1,403,398 was granted on September 2, 2024 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The award supports research aimed at utilizing advanced imaging approaches to develop imaging-based biomarkers related to the hybrid epithelial/mesenchymal state (HEM) and its interactions with the immune system in head and neck squamous cell carcinoma (HNSCC)....