The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under its Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division, to support research on targeting senescent cells for alleviating temporomandibular joint (TMJ) degeneration. The $350,000 grant, awarded on September 5, 2024, aims to define the role of p21-positive senescent cells in...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to identify the cellular origins of cartilage regeneration in the zebrafish jaw joint. The $143,285 award to the University of Southern California aims to optimize a transgenic model for joint cartilage ablation and investigate the sources of regenerating cartilage, such as the perichondrium, deeper...
This federal Cooperative Agreement award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121), aims to conduct multi-omic investigations of temporomandibular joint (TMJ) disorders. The $587,428 award will support a two-phase project at the University of California, Los Angeles (UCLA) to: 1) develop protocols and infrastructure for data management, subject recruitment, and sample collection; and 2)...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $429,000.00 to the Regents of the University of Michigan to conduct research on the unique characteristics of jawbone biology. The research aims to gain a molecular-level understanding of how osteoblasts in the jawbone respond differently to bone morphogenetic protein (BMP) signaling and mechanical loading...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
This federal Project Grant award, valued at $161,762.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of the NG2/CSPG4 protein in the healing of endochondral fractures in the mandible. The research aims to define the specific molecular pathways by which NG2/CSPG4 regulates the differentiation of osteochondral progenitor cells during fracture repair, with the...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,831,197 to Emory University to conduct research on nociplastic pain mechanisms in temporomandibular disorders (TMD). The research project aims to separate nociceptive (stimulus-evoked) sensitivity from pain sensitivity using novel quantitative sensory testing methods, in order to better understand the...
This Project Grant award, totaling $2,743,242, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The project aims to identify individual host factors associated with the need for opioid analgesics in addition to non-steroidal anti-inflammatory drugs (NSAIDs) following third molar extraction. Specifically, the research will investigate the role of inter-individual differences in...
This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to investigate the mechanisms behind varied success of bone morphogenetic protein-2 (BMP-2) in palatal versus mandibular bone repair. The $129,420 award to The Leland Stanford Junior University, which runs from March 2025 to February 2027, focuses on two key objectives: 1) identifying how BMP-2-based palatal...