This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $239,405 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the neural circuit mechanisms of peripheral nerve stimulation for trigeminal neuropathic pain. The project aims to examine the role of the thalamic reticular nucleus, particularly parvalbumin-expressing neurons, in mediating the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will evaluate the safety and analgesic efficacy of a marine oil supplement containing specialized pro-resolving mediators for the treatment of chronic temporomandibular disorder (TMD) pain in adults. The $603,502 award will fund a 12-month, triple-masked, randomized, placebo-controlled clinical trial that...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $238,668 to the University of Connecticut to diagnose and differentiate dental pain from stress using a wearable electrodermal activity (EDA) device. The project aims to develop a quantitative approach to separate stress from pain response in EDA signals by leveraging skin nerve activity (SKNA) data derived from...
This Project Grant award, totaling $2,743,242, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The project aims to identify individual host factors associated with the need for opioid analgesics in addition to non-steroidal anti-inflammatory drugs (NSAIDs) following third molar extraction. Specifically, the research will investigate the role of inter-individual differences in...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $162,743 to New York University (NYU) to conduct research on the role of Schwann cells and the TRPV4 ion channel in oral cancer pain mechanisms. The 5-year award, which commenced on March 10, 2025, aims to develop and validate new methods for measuring pressure and stretch sensitivity associated with oral cancer...
This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
This federal Cooperative Agreement award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121), aims to conduct multi-omic investigations of temporomandibular joint (TMJ) disorders. The $587,428 award will support a two-phase project at the University of California, Los Angeles (UCLA) to: 1) develop protocols and infrastructure for data management, subject recruitment, and sample collection; and 2)...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,831,197 to Emory University to conduct research on nociplastic pain mechanisms in temporomandibular disorders (TMD). The research project aims to separate nociceptive (stimulus-evoked) sensitivity from pain sensitivity using novel quantitative sensory testing methods, in order to better understand the specific pain processing mechanisms present in TMD patients. The goal is to develop new clinical biomarkers for assessing nociception and pain in isolation, which could lead to improved diagnostics and treatment approaches for nociplastic pain conditions. The award period runs from August 1, 2024 to July 31, 2026.