Project Grant R21DA066044
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $159,615 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2025, for research extending through June 30, 2027. This K99/R00 award supports a research initiative titled "Predicting Craving and Relapse Using Neurobehavioral Markers of Goals and Habits in Opioid Use Disorder." The project delivers longitudinal neurobehavioral...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $431,643 under its Drug Use and Addiction Research Programs (CFDA 93.279) to The Research Foundation for the State University of New York (SUNY at Binghamton) on August 1, 2025, for a two-year project concluding July 31, 2027. This Project Grant funds the development and pilot testing of a telehealth-delivered, pain-targeted motivational smoking intervention designed for smokers with chronic pain who are not ready to...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $198,164 to the University of Pittsburgh under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 25, 2025, with a completion date of April 30, 2028. The grant funds research investigating Delta Opioid Receptor (DOR) regulation of parvalbumin interneuron transmission and oxycodone-related behavior in the context of opioid use disorder (OUD). The research addresses a critical...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $787,594 under the Drug Use and Addiction Research Programs (CFDA 93.279) for research on the cortical mechanisms of opioid reinforcement. The award, effective September 1, 2025, through May 31, 2030, supports a comprehensive research program investigating the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $529,990 to Michigan State University (operating as Henry Ford Health+Michigan State University Health Sciences) on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test an adaptive psychological intervention designed to reduce prolonged opioid use among hospitalized patients recovering from musculoskeletal injuries. The intervention employs a tiered approach...
- Federal Project Grant Award Summary New York University School of Medicine received a $2.09M project grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded July 1, 2025, with completion targeted for March 31, 2030. This research initiative characterizes complex Opioid Use Disorder (OUD) care trajectories and outcomes following acute service utilization through a population-based data linkage study. The project applies...
- Federal Project Grant Award Summary Praeventix LLC received a $355,190 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period of June 1, 2026 through May 31, 2027. The award supports in vivo preclinical research characterizing 5-HT7 (serotonin 7 receptor) modulators in rat models of opioid use disorder (OUD). The research program will evaluate the impact of novel 5-HT7 antagonists, including the lead...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $1,517,762 Project Grant (CFDA 93.279: Drug Use and Addiction Research Programs) effective July 1, 2025, through March 31, 2030. The award supports research leveraging integrative computational modeling and artificial intelligence-based tools to develop safer opioid therapeutics. The research addresses the critical public health challenge of opioid misuse and overdose...
- Federal Cooperative Agreement Summary The Research Foundation For Mental Hygiene, Inc., through its New York State Psychiatric Institute division, received a $717,986 Cooperative Agreement award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 15, 2026, with completion targeted for April 30, 2028. This award supports a UG3-UH3 phased research initiative to evaluate the efficacy of transcutaneous auricular...
The National Institute on Drug Abuse (NIDA) awarded $450,175 under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Research Foundation For Mental Hygiene, Inc., through its New York State Psychiatric Institute division, to conduct a clinical research study investigating the efficacy of sphenopalatine ganglion (SPG) nerve blocks as an adjunctive treatment for opioid use disorder (OUD). The award, effective May 15, 2026, through April 30, 2028, funds an eight-week exploratory/developmental (R21) study enrolling 40 individuals with OUD who test positive for high-potency synthetic opioid use. All participants receive standard transmucosal buprenorphine maintenance therapy while being randomized to receive either active or sham SPG blocks, with the initial block administered prior to buprenorphine induction and subsequent weekly procedures performed throughout the study period. The primary deliverables include measurement and analysis of opioid withdrawal symptom severity using the Clinical Opiate Withdrawal Scale and assessment of treatment acceptability through procedure adherence rates. The research will generate a 95% confidence interval for the treatment effect size between active and sham SPG block interventions to inform the design of future, larger-scale clinical trials. This investigation addresses the evolving opioid epidemic driven by high-potency synthetic opioids such as fentanyl and contributes to NIDA's priority of developing new treatment approaches for substance use disorders and reducing overdose-related health outcomes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.2k | 5/14/26 |