Project Grant R21DA065065
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 15, 2025, with completion scheduled for August 31, 2027. This R21 exploratory grant funds fundamental neuroscience research investigating the neurobehavioral consequences of fentanyl overdose and their relationship to relapse risk in individuals with opioid use...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a project grant of $116,865 under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of locus coeruleus mu opioid receptors in fentanyl drug seeking. The award, effective from August 3, 2026, through February 28, 2029, supports research aimed at addressing the growing opioid epidemic by establishing the specific neurobiological mechanisms underlying...
- Federal Project Grant Award Summary New York University has been awarded $201,250 by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for a two-year project period from June 1, 2025, through May 31, 2027. This Project Grant supports basic neuroscience research investigating the synaptic organization of cholinergic interneurons in the nucleus accumbens, a brain region critical to motivated behaviors and implicated in substance use...
- FEDERAL PROJECT GRANT AWARD SUMMARY The National Institute on Drug Abuse (NIDA) awarded a $490,179 Project Grant (CFDA 93.279: Drug Use and Addiction Research Programs) to the University of Texas at Austin on May 15, 2026, for research investigating the neurobiological mechanisms mediating fentanyl-induced elevations in risk-taking behavior in rats. The five-year project, concluding February 28, 2031, addresses a critical knowledge gap regarding how synthetic opioids impair decision-making and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a $577,531 Project Grant on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a multiomic analysis of brainstem respiratory control regions in fentanyl overdose decedents. The research will generate the first single-nucleus paired RNA sequencing and single-nucleus assay for transposase-accessible chromatin sequencing (multiome) data from the...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded the University of Cincinnati a Project Grant totaling $1,723,975 on July 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct translational research on single-cell opioid and fentanyl responses in the context of HIV infection. The research employs a multi-omics approach combining in vivo and ex vivo studies to evaluate the impact of fentanyl on peripheral blood mononuclear cell (PBMC)...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Minnesota a $673,724 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2026, through February 28, 2031. This research initiative will investigate how opioid exposure modifies nucleus accumbens microcircuits, with the ultimate goal of reversing or preventing maladaptive neuroplastic changes associated with opioid addiction. The project...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $438,950 under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Board of Regents of the University of Nebraska, operating through the University of Nebraska Medical Center (UNMC) in Omaha. The award, made on May 1, 2026, supports an R21 exploratory/developmental research grant with a project completion date of April 30, 2028. The research investigates the mechanisms underlying polysubstance use (PSU)...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Nebraska Medical Center (UNMC) a Project Grant totaling $544,256 under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of microglial ferritinophagy in HIV and cocaine-mediated neuroinflammation. The research project, initiated May 15, 2026 and concluding February 28, 2031, addresses the persistent neuroinflammation and cognitive decline experienced by approximately...
Tulane University received a $229,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2026, through April 30, 2028. The grant funds basic research to elucidate novel mechanisms of protective immunity against neurotropic substances of abuse, including fentanyl, cocaine, and nicotine. The research responds to the critical public health burden of substance use disorders (SUDs), including over 100,000 annual U.S. overdose deaths from fentanyl and 435,000 deaths related to nicotine addiction. The award builds upon preliminary findings demonstrating that fentanyl vaccination with specific adjuvants and delivery routes blocks drug-induced analgesia and brain penetration, with fentanyl-specific IgA antibodies correlating most strongly with protective immunity. The research deliverables include three primary studies: (1) testing whether targeted depletion of meningeal plasma cells eliminates protective immunity against SUDs in a mouse model; (2) employing two-photon cranial window imaging to determine in real-time how meningeal plasma cells correlate to protection against SUDs; and (3) determining whether specific antibody isotypes (such as IgA) or antibody locations (cerebrospinal fluid versus serum) provide protective phenotypes. These basic research findings are intended to inform the development of therapeutic strategies that could help prevent relapse and reduce addiction-related mortality.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $229.5k | 4/27/26 |