Project Grant R21DA062200
- The National Institute on Drug Abuse awarded the University of California, San Diego $3,001,884 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 1, 2026, to conduct translational and cross-species studies of cannabis use and HIV effects on mitochondrial homeostasis in brain macrophages. The research combines a clinical observational study with cellular and in vivo preclinical models to determine how cannabis use affects TREM2-mediated changes in mitochondrial function...
- The National Institute on Drug Abuse awarded the University of California, San Diego $402,874 under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2026. The recipient will implement ecological mobile health tools to evaluate short-term prospective relationships between neurobiological functioning and cannabis use in healthy adults. The study combines laboratory-based and ecological mobile assessments administered over a four-week home monitoring period. Smartwatches will...
- The National Institute on Drug Abuse awarded the University of Southern California $149,766 on August 12, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate simultaneous nicotine, alcohol, and cannabis co-use among young adults. The funded research examines patterns of use, subjective experiences, and consequences of simultaneous substance co-use—defined as using multiple substances close in time so their effects overlap—among approximately 3,860 young adults...
- The National Institute on Drug Abuse awarded the Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $195,804 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds a five-year research project examining how cannabis influences nicotine use among young and emerging adults (ages 18–35) who use electronic nicotine delivery systems. The study integrates human laboratory methods with...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,468,376 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026, to conduct a prospective study characterizing sex-specific cannabinoid and endocannabinoid biomarkers as predictors of neuropsychological, behavioral, and withdrawal outcomes during cannabis abstinence in emerging adults. The research will recruit 220 participants aged 18–25 (balanced by sex, 64 percent with heavy...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,233,586 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate epigenetic and neuroimmune mechanisms underlying cannabis-cannabinoid neuroimmunomodulation in people living with HIV. The recipient will conduct integrated clinical, postmortem, and mechanistic research examining how THC and CBD reshape the neuroimmune axis in people living with HIV through...
- The National Institute on Drug Abuse awarded the University of California, San Diego $142,161 on August 19, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research examining the impact of cannabis use on visual functioning and visuospatial neuropsychological performance in cannabis users with and without HIV. The research will examine performance on visuospatial neuropsychological assessments predicted to indicate driving safety in cannabis users stratified...
- The National Institute on Drug Abuse awarded Duke University $731,879 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the impact of cannabis use on the inflammasome in people with HIV compared to HIV-seronegative persons. The research leverages biospecimens from a cohort of clinically and neurologically phenotyped HIV-infected cannabis users and non-users to determine how recreational cannabis use modulates the NLRP3 inflammasome and its effects on...
- The National Institute on Drug Abuse awarded The Leland Stanford Junior University $160,840 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate TRPV1-mediated vascular and neuronal dysregulation induced by natural and synthetic cannabinoids. The research examines differential impacts of natural cannabinoids (cannabidiol, delta-9-tetrahydrocannabinol) and synthetic cannabinoids (cannabinol, hexahydrocannabinol) on vascular and neuronal function, with...
- The National Institute on Drug Abuse awarded Carnegie Mellon University $191,250 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate THC exposure and inhibitory circuit plasticity in the neocortex. The research examines acute and long-term effects of tetrahydrocannabinol (THC), the main psychoactive component of cannabis, on neocortical interneurons expressing the highest levels of cannabinoid receptors in the mammalian brain. The project will...
The National Institute on Drug Abuse awarded The Regents of the University of California, San Francisco $246,000 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the concurrent use of cannabis and stimulant medications on cardiovascular disease risk. The research will evaluate whether cannabis smoking and prescribed stimulant medication used together exert additive or synergistic effects on cardiovascular function and circulating biomarkers of cardiovascular risk. The study will recruit four groups—cannabis smokers, stimulant medication users, individuals using both substances, and non-users—and assess cardiovascular function through arterial flow-mediated dilation, pulse wave velocity, blood pressure, and electrocardiogram monitoring. Researchers will analyze circulating biomarkers including platelet aggregation rate and markers of inflammation, oxidative stress, and tissue fibrosis to determine whether concurrent use leads to exacerbated vascular impairments compared to single-use groups. Work is performed in San Francisco, California, with a period of performance from September 1, 2026, through August 31, 2028. This R21 exploratory research project is a Project Grant, the assistance type supporting hypothesis-driven inquiry in substance use research under the NIDA program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $246.0k | 8/27/26 |