Project Grant K99DA064783
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Leland Stanford Junior University a $744.7K Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective April 1, 2026, through March 31, 2028. This award funds a hybrid research trial designed to develop and test evidence-based family engagement strategies during early substance use disorder (SUD) treatment. The project addresses the significant mental and physical health...
- Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Leland Stanford Junior University a Project Grant totaling $158,534 under the Drug Use and Addiction Research Programs (CFDA 93.279), with an award date of May 15, 2026, and completion target of April 30, 2028. This grant funds basic research investigating opioid-induced dopamine rhythms and their mechanistic role in opioid-induced respiratory depression (OIRD), a critical public health issue given that opioid...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Regents of the University of California, San Francisco a $1.21 million Project Grant effective September 1, 2025, through May 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This award supports basic research investigating compartmentalized dopamine signaling in the brain, specifically examining how D1 dopamine receptors signal from both the plasma membrane and Golgi...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Leland Stanford Junior University a $692,570 Project Grant (CFDA 93.279: Drug Use and Addiction Research Programs) effective June 1, 2026, through March 31, 2031, to develop epidemiological modeling and economic analyses addressing the intersection of opioid use disorder (OUD) and homelessness. The project will deliver computational models assessing the impact of housing provision and medication-assisted...
- Federal Grant Award Summary Award Overview Washington State University received a $420,750 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded July 15, 2026, with a completion date of June 30, 2028. The award funds research to investigate the neurobiological substrates underlying cannabis-seeking behavior, specifically examining how dynamic neural activity and dopamine release in brain circuits correlate with...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a $708,190 Project Grant effective July 1, 2026 through May 31, 2031 under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant funds a controlled clinical research initiative examining the pharmacokinetic and pharmacodynamic effects of varying tetrahydrocannabinol (THC) to cannabidiol (CBD) ratios in cannabis edibles. The research comprises two double-blind,...
- Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $385,638 to The Regents of the University of Colorado (University of Colorado-Denver) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2025, with a completion date of August 31, 2028. This research award funds a three-year neurobehavioral investigation titled "Cannabinoid Tolerance Across Neurodevelopment: Disruption of Value-Driven Behavior and Prevention Through...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $465,250 Project Grant to The Johns Hopkins University, effective September 1, 2025 through August 31, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279). The research project investigates pregnenolone as a potential therapeutic treatment for cannabis intoxication, a clinical condition currently lacking any FDA-indicated medications despite increasing emergency room visits related to...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Texas Health Science Center at Houston a $1.489 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. The project focuses on identifying fetal neuronal extracellular vesicle (CNSEVs) biomarkers to predict neurodevelopmental derangements in fetuses exposed to maternal cannabinoid use during pregnancy. The research...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $211,680 Project Grant to the Medical University of South Carolina (MUSC) on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize hemp-derived alternative cannabinoid product use in real-world environments through mixed-methods research. The five-year project (completion July 31, 2031) will conduct two complementary national studies: an online survey and a six-month...
The National Institute on Drug Abuse (NIDA) awarded The Leland Stanford Junior University a $160,840 Project Grant effective August 1, 2026, through July 31, 2028, under the Drug Use and Addiction Research Programs (CFDA 93.279). This K99/R00 award funds a two-year research initiative investigating the differential vascular and neuronal effects of natural cannabinoids (such as cannabidiol and delta-9-tetrahydrocannabinol) versus synthetic cannabinoids (such as cannabinol and hexahydrocannabinol), with particular emphasis on TRPV1-mediated dysregulation. The research deliverables include mechanistic characterization of cannabinoid-induced endothelial dysfunction and neuronal toxicity using induced pluripotent stem cell (iPSC)-derived endothelial cells and cortical neurons from a genetically diverse "cell village" model of 20 healthy donors, complemented by in vivo studies in adolescent rats assessing vascular function, neuroinflammation, and cognitive outcomes. The project is structured around three specific aims: (1) investigation of TRPV1-mediated endothelial dysfunction; (2) evaluation of cannabinoid impacts on neuronal function through direct exposure and endothelial-conditioned media mechanisms; and (3) translation of findings to in vivo models with integration of human data to inform regulatory policies and therapeutic applications. Research is conducted at Stanford's Palo Alto, California location under mentorship from primary advisor Dr. Joseph Wu and co-advisor Dr. Erin Gibson, with support from an advisory committee of vascular biology and neuroinflammation experts. The anticipated outcomes will contribute to evidence-based understanding of cannabinoid safety profiles relevant to public health policy and therapeutic development.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $160.8k | 7/16/26 |