Project Grant R21DA060954

Award Date 9/1/24
Completion Date 8/31/26
Dollars Obligated $212K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
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This Project Grant award of $147,486 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund two multi-method studies to characterize the impact of the veterinary tranquilizer xylazine on people who use drugs (PWUD) in North Carolina and Maine. The first study in North Carolina aims to describe PWUD's perceptions, experiences, and the impacts of xylazine, including related complications like wounds and overdoses, through surveys...
The National Institute on Drug Abuse (NIDA) awarded a $907,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Tufts University School of Medicine. The grant, titled "Examination of Xylazine Exposure and the Risk of Skin and Soft Tissue Infections in People Who Inject Drugs," will fund a 3-year study to prospectively recruit 200 people who inject drugs (PWID) in Lowell, Massachusetts and examine the association between xylazine exposure and the...
This Project Grant award of $1,607,146.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of a technology-based intervention to encourage drug checking, distribution of harm reduction supplies, and linkage to services for people who use drugs. The project, titled "Together Against Overdose: Community Developed Technology to Encourage Drug Checking, Distribution of Harm Reduction Supplies, and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will provide $231,000 to the University of Rochester to conduct research on the pharmacological properties of the drug xylazine and its metabolites. The key objectives are to determine if xylazine and its metabolites act as agonists, antagonists, or positive allosteric modulators at the mu and kappa opioid receptors, as well as the sigma 1 and sigma...
This Project Grant award of $688,271, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a research project at Yale University to examine spatial and temporal variability in a state's illicit drug market. The key activities under this award include: 1) Expanding street-based testing of drug samples from individuals who use drugs, 2) Developing a wastewater sampling and testing system to determine community-level drug...
The National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $460,432 Project Grant to the Regents of the University of Minnesota to develop and pilot a comprehensive telehealth program at syringe service programs (SSPs) to engage people who inject drugs (PWID) into the HIV care continuum. The key products and services to be delivered include: Conducting formative research to understand determinants of HIV and addiction among...
This Project Grant award, with an ID of R21DA061281, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $266,742 grant will fund a two-year qualitative study to characterize transitions to low-frequency injecting and injection cessation among people using xylazine-adulterated fentanyl in Connecticut. The study aims to (1) understand how exposure to xylazine-adulterated fentanyl intersects with social-structural...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $506,000.00 to the Scripps Research Institute to prepare and investigate monoclonal antibodies that can block the mechanism of action and adverse effects of the drug xylazine. Xylazine has been increasingly detected as an adulterant in illicit drug mixtures and is linked to a growing number of overdose deaths. The research aims to generate a...
This Project Grant award of $1,322,026.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a community-based, longitudinal study to investigate the growing crisis of injection-related wounds and skin and soft tissue infections (IWSTIs) among people who inject drugs (PWID) in North Carolina. The key products and services to be delivered under this grant include: 1) Observing, examining, and categorizing IWSTIs...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $238,500 to the University of Pittsburgh to conduct research on the effects of xylazine and opioids on prefrontal cortex inhibitory transmission. The research aims to understand xylazine's cell signaling profiles and interactions with opioids at the circuit level, as xylazine is becoming highly prevalent in illicit opioid supplies and poses an...

This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $212,200 to the Research Triangle Institute (RTI International) to conduct a 24-month mixed-methods study examining the feasibility and acceptability of a community-based drug checking (CBDC) program operating through a syringe service program (SSP) in rural and tribal communities in Minnesota.

The goal is to use the CBDC program to collect real-time information about the presence of xylazine in the illicit drug supply and provide individuals with information about their drugs, along with referrals to treatment and services. A sub-award of $23,120 was made to Public Health Foundation Enterprises, Inc. (Heluna Health) to provide administrative and fiscal support for the project. The study has strong public health potential to mitigate harms from xylazine and other cutting agents by improving understanding of this emerging harm reduction strategy in underserved communities.

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