This federal Project Grant award, with an ID of R21DA061044, is funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $231,000 grant, awarded on May 1, 2025, supports research to determine if the drug xylazine and its metabolites act as agonists or positive allosteric modulators at the mu and kappa opioid receptors. Additionally, the research will examine if xylazine and its metabolites are agonists, antagonists, or inverse agonists at the sigma 1 and sigma 2 receptors. This work aims to better understand the pharmacological properties of xylazine, which is increasingly being mixed with other illicit drugs, in order to explain the physiological effects observed in people using these drug combinations. The project will be conducted by researchers at the University of Rochester, a private research university with extensive capabilities in supporting federal government research and development.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $231.0k | 4/18/25 |