Project Grant R21DA061044

Award Date 5/1/25
Completion Date 4/30/27
Dollars Obligated $231K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
New York, USA
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This $238,500 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research investigating the effects of xylazine and opioids on inhibitory transmission in the prefrontal cortex. The key objectives are to: Test whether xylazine and opioids have synergistic effects on prefrontal cortex inhibitory transmission through distinct molecular mechanisms. Determine if xylazine and opioids inhibit...
This federal Project Grant award of $392,940 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the behavioral pharmacology of opioid and xylazine mixtures. The project aims to improve understanding of the interactions between opioids and xylazine, a non-opioid veterinary drug that has emerged as an adulterant contributing to the opioid crisis. The proposed studies will use well-established experimental methods...
This $387,750 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research on the molecular pharmacology of the drug xylazine and its relation to necrotizing skin lesions associated with chronic intravenous administration. The research project, to be conducted by Mercer University, will assess the binding affinity and functional effects of xylazine compared to other adrenergic receptor agonists...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $408,486 community-based, longitudinal, mixed-methods study to investigate the growing crisis of xylazine exposure among people who use drugs (PWUD) in the Southeastern United States. The key objectives are to: 1) Employ community-based drug checking to determine xylazine's prevalence in the illicit drug supply; 2) Explore...
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This federal Project Grant award, with an ID of R21DA061044, is funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $231,000 grant, awarded on May 1, 2025, supports research to determine if the drug xylazine and its metabolites act as agonists or positive allosteric modulators at the mu and kappa opioid receptors. Additionally, the research will examine if xylazine and its metabolites are agonists, antagonists, or inverse agonists at the sigma 1 and sigma 2 receptors. This work aims to better understand the pharmacological properties of xylazine, which is increasingly being mixed with other illicit drugs, in order to explain the physiological effects observed in people using these drug combinations. The project will be conducted by researchers at the University of Rochester, a private research university with extensive capabilities in supporting federal government research and development.

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