This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the NIH's Drug Use and Addiction Research Programs (CFDA 93.279), provides $201,250 in funding to The Research Foundation For The State University Of New York (RF SUNY) to investigate the role of astrocyte mitochondria oxidative phosphorylation in heroin-induced plasticity. The key objectives are to: 1) Identify the contribution of astrocyte mitochondria in mediating heroin-induced plasticity by knocking down...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,039,420 to The Medical University of South Carolina (MUSC) to conduct research on the neurobiological mechanisms underlying the facilitation and disinhibition of opioid and alcohol seeking behaviors. The key goals of this 5-year project are to: 1) characterize the transcriptomic profiles and functional roles of unique neuronal...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research to investigate the molecular mechanisms underlying astrocytic CREB's regulation of cocaine drug-seeking behavior. The $180,646 award, spanning from December 2024 to November 2029, will be conducted by the Icahn School of Medicine at Mount Sinai. The research aims to elucidate the transcriptional and epigenetic regulation of astrocytes in...
This federal Project Grant award, with ID R01DA061766, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $903,965 award, with a project period from April 1, 2025 to January 31, 2030, supports research by the University of Alabama at Birmingham (UAB) to investigate the role of prefrontal cortex circuits in controlling heroin seeking behavior. The key focus is on identifying distinct driver and limiter circuits...
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $451,000.00 to investigate the effects of environmental enrichment on reversing the neural and behavioral adaptations caused by chronic heroin use in rats. The award period runs from September 10, 2024 to June 30, 2028. The research aims to: 1) characterize dopamine release adaptations in the ventral tegmental area and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the NIH's Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $751,043 research project at the University of Massachusetts Medical School focused on investigating the cellular and molecular mechanisms underlying the complex co-morbidity of opioid use disorder (OUD), major depressive disorder (MDD), and HIV in the human brain. The project will leverage single-cell sequencing technologies and other...
This $254,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize a specialized serotonergic-septohippocampal brain circuit and its role in modulating context-triggered drug-seeking behavior and relapse vulnerability. The research will be conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, from July 2024 through June 2026. Specifically, the grant...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports research to identify and validate G protein-coupled receptors (GPCRs) expressed by somatostatin-expressing inhibitory neurons in the prefrontal cortex as potential targets for developing new treatments for opioid use disorder. The $1,717,200 award, spanning August 1, 2024 to May 31, 2029, will enable researchers at the University of...