Project Grant R21CA309638
- Federal Grant Award Summary Boston Medical Center Corporation received a $178,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded June 11, 2026, with completion targeted for May 31, 2028. The award funds research to develop personalized spatial regulatory networks that decode the tumor microenvironment in triple-negative breast cancer (TNBC). The project will deliver a cost-effective, scalable methodology integrating spatial...
- Federal Grant Award Summary Award Overview The National Cancer Institute (NCI) awarded Rutgers The State University of New Jersey, School of Nursing, a $170,930 Project Grant under the Cancer Biology Research program (CFDA 93.396) for the period April 1, 2026, through March 31, 2028. The award supports research on the longitudinal dynamics of blood microbiome and circulating tumor cells (CTCs) in metastatic breast cancer, with a sub-award to Thomas Jefferson University's Sidney Kimmel Medical...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Icahn School of Medicine at Mount Sinai a $2.69 million Project Grant under the Cancer Biology Research program (CFDA 93.396) on September 24, 2025, with completion scheduled for August 31, 2029. This award supports fundamental research investigating the mechanisms and impact of Neuregulin 3 (NRG3) induction in bone metastasis of breast cancer. The project will employ molecular and genetic approaches to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration – School of Medicine a $254,333 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) effective September 23, 2025, with completion by August 31, 2027. This award funds research investigating racial disparities in breast cancer risk and gene expression, specifically examining the roles of genetic and lifestyle factors. The...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Texas at Austin a $626,203 Project Grant on July 16, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate the mechanisms linking obesity to prostate cancer progression through DNA structure-induced genetic instability. The research will be conducted through June 30, 2031, and focuses on elucidating how obesity increases mutagenesis at H-DNA sequences—alternative DNA...
- Federal Project Grant Award Summary The National Cancer Institute awarded Albert Einstein College of Medicine a $431,970 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective July 1, 2026, through June 30, 2028. The award supports development and validation of TDAM (Tumor Microenvironment of Metastasis Doorway Activity-MRI), a non-invasive magnetic resonance imaging technique designed to detect and measure the activity of specialized intravasation...
- Federal Grant Award Summary Health Research, Inc. at Roswell Park Division received a $446,112 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on July 3, 2026, with an ultimate completion date of June 30, 2028. The award funds fundamental cancer biology research focused on identifying age-regulating breast cancer dormancy genes. The research employs Caenorhabditis elegans (C. elegans) dauer models as a novel screening...
- Federal Grant Award Summary The National Cancer Institute awarded a $425,573 Project Grant to Magee-Womens Research Institute and Foundation under the Cancer Treatment Research program (CFDA 93.395) for the period of July 1, 2025 through June 30, 2027. The grant funds research to identify specific gut bacteria species, metabolites, and metabolic pathways associated with mammographic breast density (MBD) as a modifiable risk factor for breast cancer prevention. The research will employ...
- Federal Grant Award Summary The National Cancer Institute (CFDA 93.393, Cancer Cause and Prevention Research) awarded a $696,498 Project Grant to The MGH Institute of Health Professions, Inc., effective May 1, 2026 through April 30, 2031, to develop and optimize a multicomponent intervention designed to improve functional recovery and participation in valued activities among breast cancer survivors. Approximately one-third of breast cancer survivors experience restrictions in vocational, social,...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 14, 2026 through April 30, 2028. The award supports fundamental research investigating the role of incretin mimetics—medications currently used to treat obesity—in reducing the risk of development and progression of multiple myeloma (MM) and its precursor condition,...
Award Details: Research Products and Services: This Project Grant supports basic and translational research aimed at identifying predictive and prognostic adipome biomarkers in obese triple-negative breast cancer (TNBC) mouse models to inform targeted therapy development. The research project investigates how obesity-modified adipocyte-derived extracellular vesicles (adipomes) regulate epithelial-mesenchymal transition, cancer stemness, and transcriptional reprogramming in both normal and malignant mammary cells. Specifically, the funded work characterizes lipid and RNA cargo differences between adipomes derived from tumor-associated versus non-tumoral mammary fat, examines epigenetic mechanisms linking obesity to TNBC progression (particularly through HSPA1B gene methylation and HSP70-2 expression), and maps molecular pathways that promote metastatic dissemination. The project delivers mechanistic insights into how host metabolic status shapes tumor biology, with the ultimate objective of identifying obesity-dependent biomarkers that can be translated into clinical therapeutics for improved TNBC outcomes in obese patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.3k | 7/16/26 |