Project Grant R03CA308463
- Federal Project Grant Award Summary The National Cancer Institute awarded $399,829 to the University of North Carolina at Chapel Hill under the Cancer Biology Research program (CFDA 93.396) for a two-year project (September 1, 2025–August 31, 2027) investigating the role of Fusobacterium nucleatum in breast cancer progression and therapeutic resistance. The research will characterize how this bacterium, detected in approximately 30% of breast cancer cases, alters the tumor microenvironment and...
- Federal Grant Award Summary Rutgers The State University of New Jersey received a $516,808 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective June 1, 2026 through May 31, 2031. The award supports fundamental research to elucidate the mechanism of targeting methionine synthase (MTR) to enhance anti-tumor immunity in KRAS-driven non-small cell lung cancer (NSCLC). The research addresses the critical clinical challenge of...
- Federal Grant Award Summary The National Cancer Institute awarded a $425,573 Project Grant to Magee-Womens Research Institute and Foundation under the Cancer Treatment Research program (CFDA 93.395) for the period of July 1, 2025 through June 30, 2027. The grant funds research to identify specific gut bacteria species, metabolites, and metabolic pathways associated with mammographic breast density (MBD) as a modifiable risk factor for breast cancer prevention. The research will employ...
- Federal Grant Award Summary The National Cancer Institute awarded the University of South Alabama a Project Grant totaling $369,868 under the Cancer Biology Research program (CFDA 93.396) to investigate intercellular mitochondrial transfer between nerve cells and triple-negative breast cancer (TNBC) cells at the nerve-cancer interface. Awarded on July 7, 2025, with a completion date of May 31, 2030, this research addresses the functional role of cancer neurogenesis in metastasis and tumor...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $160,431 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to the University of Tennessee Health Science Center, effective December 1, 2025. This F31 fellowship grant supports predoctoral research training focused on investigating the mechanistic relationship between gut microbiome modulation and breast cancer (BC) outcomes in the context of obesity and weight loss. The research aims to identify...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey (RBHS-School of Nursing) received a $197,414 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on August 7, 2025, with completion targeted for July 31, 2030. This award supports a K01 (Mentored Research Development) grant designed to develop an early-career investigator's research capacity and expertise in studying dyadic and social network influences...
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded the Regents of the University of Michigan a $2.86 million Project Grant on September 10, 2025, with a completion date of August 31, 2029. This research initiative develops novel therapeutic strategies to combat colibactin, a carcinogenic metabolite produced by pathogenic enteric bacteria associated with colorectal cancer (CRC). The project delivers two primary products: (1) an...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $660,541 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center, with an award date of April 1, 2026 and completion date of March 31, 2031. This five-year research initiative investigates the modulation of the tumor microenvironment by Fusobacterium nucleatum (FN) and co-infecting microbes in colorectal cancer (CRC). The project addresses a critical...
- Federal Grant Award Summary Rutgers The State University of New Jersey, Robert Wood Johnson Health Sciences (RBHS)-School of Nursing received a $403,689 Project Grant award from the National Cancer Institute (NCI) effective August 1, 2025, through July 31, 2027, under the Cancer Cause and Prevention Research program (CFDA 93.393). The grant funds research investigating the influence of menthol cigarette smoking on lung cancer screening eligibility within a national prospective cohort study....
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Rutgers The State University of New Jersey, School of Nursing a $654,688 Project Grant on April 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a comprehensive retrospective analysis of flavored cigar policy implementation across U.S. municipalities. The research will extend through March 31, 2031, and is designed to identify evidence-based strategies for implementing local public...
The National Cancer Institute (NCI) awarded Rutgers The State University of New Jersey, Robert Wood Johnson Medical School (RBHS-School of Nursing) a $170,930 project grant under the Cancer Biology Research program (CFDA 93.396) effective April 1, 2026, through March 31, 2028. This research project investigates the longitudinal dynamics of blood microbiome composition and circulating tumor cells (CTCs) in metastatic breast cancer patients, with particular focus on triple-negative breast cancer (TNBC). The research leverages novel reduced metagenomic sequencing techniques applied to liquid biopsy plasma samples to non-invasively assess microbial and tumor cell features in real-time, addressing a critical gap in understanding how intratumoral microbiota contributes to metastatic progression and treatment resistance in this highly aggressive cancer subtype. The project builds upon preliminary findings demonstrating associations between low blood microbial diversity, elevated CTC counts, and increased mortality risk in metastatic TNBC populations. By conducting longitudinal analysis of plasma samples collected before and after treatment, this research aims to identify modifiable microbiome-related factors that influence disease burden and treatment outcomes. The study's findings are expected to advance fundamental understanding of cancer biology mechanisms and contribute to improved prevention, detection, and treatment strategies for metastatic breast cancer.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $170.9k | 3/23/26 |