Project Grant R03CA293127
- This Project Grant award from the National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), will support research conducted by Thomas Jefferson University to investigate genomic factors contributing to racial disparities in metastatic prostate cancer outcomes. The key products or services to be delivered under this $156,000 award include whole-exome sequencing of circulating tumor cells (CTCs) from paired Black and White patients with metastatic...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will provide $368,288 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research aimed at understanding molecular mechanisms contributing to disparate lung cancer outcomes experienced by patients of African ancestry. The research project will: 1) Determine how EGFR signaling differs based on patient genetic ancestry, 2) Quantify the interplay...
- This $3.3 million project grant from the National Cancer Institute's Cancer Cause and Prevention Research program (CFDA 93.393) supports research to identify prediagnostic exposures, germline genetics, and immune and mutational profiles associated with triple negative breast cancer (TNBC). Joan & Sanford I Weill Medical College of Cornell University is the primary awardee and will perform whole exome sequencing of tumor and germline DNA from 400 TNBC patients across four prospective cohort...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $415,257 to the University of Virginia to conduct research aimed at identifying epigenetic and transcriptomic drivers of racial disparities in colorectal cancer risk and site-specific tumor development. The key products and services to be delivered under this 2-year award include: Identifying site-specific DNA methylation-associated gene expression signatures across different...
- This $714,062 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting research at the University of California, San Francisco (UCSF) to investigate the biological mechanisms contributing to racial disparities in oral and head and neck cancer outcomes, particularly among Black patients. The key research objectives are to: 1) develop a tailored RNA prognostic model to enhance oral cancer survival predictions in Black populations by identifying...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research) provides $547,047 to Georgetown University to conduct a clinical trial testing the bundling of multicancer screening and genetic services navigation to improve cancer health equity among Black and Hispanic women. The project aims to address patient- and organization-level barriers that limit cancer screening and genetic testing rates in these populations, which experience...
- This $399,187 federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will support research at Virginia Commonwealth University to study the role of ATG16L1 isoforms in colorectal cancer health disparities. The key objectives are to: 1) Determine whether the ATG16L1 T300T isoform, which is more predominant in African Americans, promotes more aggressive colorectal tumor growth and metastasis compared to the A300A isoform found more in...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Emory University provides $659,498.00 to conduct research on racial disparities in the mechanisms of prostate cancer metastasis. The project aims to analyze differential pathway activity, particularly involving the FGFR3 signaling and oxidative phosphorylation (OXPHOS) pathways, and their impact on metastasis in African American prostate cancer patients. The research will utilize in vitro and...
- This federal Project Grant award, totaling $477,869.00, was provided by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395). The grant aims to develop tailored, multilevel cervical cancer interventions for ethnically diverse Black women, including African American women and Black African immigrant women. The key objectives are to: 1) identify multilevel determinants of routine cervical cancer screening and follow-up adherence among these populations,...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $527,159 in funding to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on the role of DNA damage and cell fate plasticity in the initiation of BRCA1-related basal-like breast cancer. The key objectives of the research are to: 1) study whether BRCA1-deficient luminal mammary cells acquire a fetal mammary stem cell-like gene expression program...
RACIAL DISPARITIES IN BREAST CANCER RISK AND GENE EXPRESSION-ROLES OF GENETICS AND LIFESTYLE FACTORS - PROJECT SUMMARY AFRICAN AMERICAN (AA) WOMEN HAVE 40% HIGHER BREAST CANCER MORTALITY AND ARE MORE LIKELY TO BE DIAGNOSED WITH AGGRESSIVE SUBTYPES, SUCH AS TRIPLE NEGATIVE BREAST CANCER, THAN EUROPEAN AMERICAN (EA) WOMEN. EXACT REASONS FOR THESE DISPARITIES REMAIN UNCLEAR - BUT GENETICS AND LIFESTYLE MAY BOTH PLAY A ROLE. HOWEVER, IT IS UNCLEAR HOW GENETIC AND LIFESTYLE FACTORS CONTRIBUTE TO RACIAL DIFFERENCES IN MOLECULAR PROFILES OF BREAST CANCER. OUR RECENT COLLABORATION WITH ZAMBIAN CANCER RESEARCHERS PRESENTS A UNIQUE OPPORTUNITY TO INCLUDE AFRICAN ZAMBIAN (AZ) BREAST CANCER PATIENTS IN RESEARCH TO HELP REVEAL THE UNDERLYING MECHANISMS FOR BREAST CANCER RACIAL DISPARITY. GIVEN THE DRASTIC DIFFERENCES IN LIFESTYLE AND ENVIRONMENTAL EXPOSURES, YET RELATIVELY SMALL GENETIC DIFFERENCES BETWEEN AA AND AZ, INCLUDING AZ, AA, AND EA BREAST CANCER PATIENTS IN ONE STUDY WILL OFFER AN EXCELLENT OPPORTUNITY TO DISENTANGLE THE CONTRIBUTION OF GENETIC PREDISPOSITIONS FROM LIFESTYLE EXPOSURES ON THE MOLECULAR PROFILES AND TUMOR CHARACTERISTICS OF BREAST CANCER. WE PROPOSE TO RECRUIT 250 INCIDENT AZ BREAST CANCER PATIENTS, COLLECT CLINICAL AND LIFESTYLE DATA, OBTAIN TUMOR TISSUES, AND PERFORMING RNA SEQUENCING (RNA-SEQ). THESE DATA WILL BE COMPARED WITH EXISTING DATA FROM THE SOUTHERN COMMUNITY COHORT STUDY. SPECIALLY, OUR STUDY HAS THE FOLLOWING AIMS: 1) TO RECRUIT 250 AFRICAN ZAMBIAN WOMEN WITH PATHOLOGICALLY CONFIRMED BREAST CANCER AT THE CANCER DISEASE HOSPITAL IN LUSAKA, ZAMBIA; 2) TO DERIVE MOLECULAR PROFILES OF BREAST CANCER IN AZ WOMEN AND COMPARE WITH THOSE FROM AA AND EA WOMEN. WE WILL PERFORM RNA-SEQ ON BREAST TUMOR TISSUE SAMPLES FROM AZ PATIENTS TO DERIVE GENE EXPRESSION LEVELS, MOLECULAR INTRINSIC SUBTYPES OF BREAST CANCER, AND PAM50-BASED RISK OF RECURRENCE SCORES (ROR-S). THE DEMOGRAPHIC, CLINICAL, AND MOLECULAR DATA WILL BE SUMMARIZED AND COMPARED ACROSS THESE THREE RACIAL/ETHNIC GROUPS. EXPRESSION LEVELS OF KNOWN BREAST CANCER SUSCEPTIBILITY GENES, MOLECULAR INTRINSIC SUBTYPES, AND ROR-S DERIVED IN AIM 2 WILL BE UTILIZED TO DISTINGUISH THE DIFFERENTIAL EFFECTS OF GENETIC ANCESTRY VERSUS LIFESTYLE ON BREAST CANCER MOLECULAR PHENOTYPE AMONG THE THREE RACIAL/ETHNIC GROUPS. THIS WILL BE THE FIRST EPIDEMIOLOGICAL STUDY TO COMPARE MOLECULAR PROFILES OF BREAST CANCER ACROSS AZ, AA, AND EA WOMEN, SHEDDING LIGHT ON THE UNDERLYING GENETIC AND LIFESTYLE FACTORS THAT CONTRIBUTE TO RACIAL DISPARITIES IN MOLECULAR PROFILES OF BREAST CANCER. THIS STUDY WILL GENERATE IMPORTANT PRELIMINARY DATA INFORMING A FULL-SCALE INVESTIGATION TO DELINEATE VARIANCES IN GENETIC PREDISPOSITIONS AND LIFESTYLE FACTORS IN ASSOCIATION WITH BREAST CANCER RISK. THIS WILL ALSO BE THE FIRST MOLECULAR EPIDEMIOLOGY STUDY OF BREAST CANCER IN ZAMBIA, LAYING THE FOUNDATION FOR CONDUCTING ETIOLOGICAL RESEARCH ON BREAST CANCER IN THE COUNTRY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $77.4k | 9/23/25 |