Project Grant R21CA308180
- Federal Grant Award Summary Health Research, Inc. (Roswell Park Division) received a $719,951 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded June 2, 2026, with a completion date of May 31, 2031. The grant funds fundamental cancer biology research investigating mechanisms underlying lung cancer lineage plasticity that facilitate adaptation and resistance to targeted therapy. The research specifically addresses how lung...
- Federal Grant Award Summary Health Research, Inc.'s Roswell Park Division received a $706,579 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2026, through July 31, 2031. The award funds hypothesis-driven basic and translational research investigating the role of innate lymphoid cells (ILC2s) in driving young-onset lung adenocarcinoma incidence in females. Specifically, the research employs metabolomic,...
- Federal Grant Award Summary Health Research, Inc. at Roswell Park Comprehensive Cancer Center received a $639,379 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded May 1, 2026, with a completion date of April 30, 2031. This award supports the development and characterization of neuroendocrine bladder carcinoma (NEBC) models to advance understanding of disease pathogenesis and improve chemotherapy response outcomes. The project...
- Federal Grant Award Summary Cold Spring Harbor Laboratory received a $704,182 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on June 16, 2026, with a completion date of May 31, 2031. The award funds fundamental research to elucidate the non-mutational mechanisms driving benign-to-malignant transition in colorectal cancer (CRC). The research employs a novel mouse model that recapitulates the stepwise acquisition of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Columbia University's Health Sciences Division a Project Grant of $448,017 under the Cancer Biology Research program (CFDA 93.396) on August 1, 2026, for a five-year project period through July 31, 2031. The award funds research to elucidate mechanisms enabling HER2-positive (HER2+) breast cancer cells to colonize and thrive in the brain, where brain metastases develop in over half of HER2+ breast cancer patients and...
- Federal Grant Award Summary Health Research, Inc. (operating as Health Research at Roswell Park) received a $173,500 Project Grant awarded August 7, 2025, by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to conduct a correlative clinical study investigating the effects of CXCR1/2 inhibition on the immune microenvironment of multiple myeloma patients. The research leverages preliminary findings demonstrating significant accumulation of CXCR2-positive...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $1.15 million Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded August 11, 2025, with completion targeted for July 31, 2030. This research initiative, titled "The Integrated Mechanobiology and Glycobiology of Bone Metastasis," addresses fundamental gaps in understanding how breast cancer cells colonize and evade immune...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $182,755.00 to Cold Spring Harbor Laboratory through the Cancer Biology Research program (CFDA 93.396) to support research on genetic technology development for elucidating lineage plasticity mechanisms in cancer. The project, which commenced on August 21, 2025, and is scheduled for completion on July 31, 2030, will deliver advanced genetic screening technologies and methodologies designed to probe lineage identity...
- Federal Project Grant Award Summary New York University School of Medicine received a $585,482 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026 through May 31, 2031. This five-year research award funds fundamental investigation into the molecular mechanisms of breast cancer metastasis, specifically examining the role of the translation initiation factor DAP5 (Death-Associated Protein 5) in selective...
- Federal Project Grant Award Summary Award Details: The National Cancer Institute (NCI) awarded Emory University a Project Grant of $572,378 under the Cancer Biology Research program (CFDA 93.396) on May 1, 2026, with a completion date of April 30, 2031. Research Products and Services: This award funds fundamental cancer biology research investigating metabolic gatekeeping mechanisms that regulate dormancy in disseminated non-small cell lung cancer (NSCLC) subpopulations. The research employs...
Health Research, Inc. at Roswell Park Division received a $446,112 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on July 3, 2026, with an ultimate completion date of June 30, 2028. The award funds fundamental cancer biology research focused on identifying age-regulating breast cancer dormancy genes. The research employs Caenorhabditis elegans (C. elegans) dauer models as a novel screening platform to rapidly validate dormancy-reactivation suppressor genes (DRSGs) previously identified through functional genomic screening in three-dimensional bone endosteal niche culture models. This approach leverages the organism's well-characterized dormancy and aging pathways, along with highly defined genetics, to circumvent the time and cost limitations of traditional in vitro dormancy models and aging-related in vivo models. The project addresses the mechanistic underpinnings of metastatic relapse in breast cancer by investigating how chronological aging of dormant cancer cells influences tumor-intrinsic and extrinsic reawakening programs. By validating candidate genes such as BHLHE41, WNT3A, and HBP1 through comparative analysis of conserved dormancy pathways between C. elegans dauers and dormant breast cancer cells, the research is expected to provide insights that support the development of therapeutically efficacious interventions to suppress metastatic recurrence and extend disease-free survival in breast cancer patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.1k | 7/6/26 |