Project Grant R21CA304850
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $249,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective January 1, 2026 through December 31, 2028. The project, "Large-Scale Artificial Intelligence Using Radiomics, Deep Learning, and Physics-Based Generative Modeling to Improve Clinical Outcomes in Nuclear Medicine," will develop AI-driven tools to enhance cancer detection and diagnosis...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,829 Project Grant effective July 1, 2026 through June 30, 2028 under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This research initiative focuses on identifying imaging biomarkers using multiplexed digital pathology data to predict clinical outcomes in breast cancer, with particular emphasis on triple-negative breast cancer (TNBC). The project applies an...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $477,674 Project Grant to The Johns Hopkins University, effective June 1, 2026 through May 31, 2031, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This research initiative focuses on molecular imaging of the immune-suppressive tumor microenvironment (TME) in prostate cancer and its response to immune checkpoint inhibitor (CIT) therapy. The project will employ molecular and functional imaging...
- Federal Grant Award Summary The National Cancer Institute awards $161,500 to the University of Virginia under the Cancer Biology Research program (CFDA 93.396) for a two-year project (June 1, 2026–May 31, 2028) focused on advancing detection and classification of circulating tumor cells (CTCs) from pancreatic ductal adenocarcinoma (PDAC) patients. The project develops complementary biophysical metrics to immunofluorescence imaging by leveraging single-cell deformability analysis to identify...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded The Johns Hopkins University a $1,020,120 Project Grant effective August 1, 2025, through May 31, 2030, to develop and clinically evaluate PROBOT, a novel ultrasound probe and robotic system designed to improve image-guided interventions for prostate cancer diagnosis and treatment. The project delivers a Phase 1 clinical trial evaluating the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Grant Award Summary The National Cancer Institute awarded a $100,228 Project Grant to The Johns Hopkins University under the Cancer Research Manpower program (CFDA 93.398) beginning December 1, 2026 and concluding November 30, 2029. This award supports research focused on engineering and optimizing mRNA-lipid nanoparticle (mRNA-LNP) vaccine compositions to enhance tissue-specific antitumor immunity. The research aims to develop cancer vaccines that can direct immune responses and...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a Project Grant totaling $591,419 under the Cancer Treatment Research program (CFDA 93.395) for the period May 1, 2026 through April 30, 2031. The grant supports the development of low molecular weight theranostics targeting cluster of differentiation 38 (CD38) protein for multiple myeloma treatment and diagnosis. The primary deliverables include creation of an 18-fluorine-labeled positron emission...
- Federal Grant Award Summary The University of Virginia received a $404,349 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period April 1, 2026, through March 31, 2028. The award funds research to quantify focused ultrasound (FUS)-mediated macromolecular delivery to brain tumors, specifically brain metastases, using advanced magnetic resonance imaging (MRI) techniques. The project addresses a critical clinical...
The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $399,829 under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period July 1, 2026 through June 30, 2028. The award supports development of Vascular Expansion Microscopy (VascExM), a novel imaging technique that combines expansion microscopy with light sheet microscopy to enable high-resolution optical visualization of brain vasculature at the endothelial cell scale. The primary deliverable is a validated VascExM protocol optimized for imaging murine brain vasculature using multiple labeling approaches—antibodies, intravascular lectins, and polymer-based contrast agents—to achieve sub-micron resolution imaging on standard diffraction-limited microscopes. The research aims to generate downloadable three-dimensional volumetric imaging datasets suitable for systems biology applications and advance understanding of neurovascular unit remodeling in neuropathologies including brain cancer and brain metastases. By establishing VascExM methodologies in murine models with intact circulatory systems, the research establishes proof-of-concept for techniques that may ultimately inform diagnostic and detection strategies in human subjects, aligning with the NCI program's focus on improving screening, early detection, and diagnostic methods for cancer.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.8k | 6/30/26 |