Project Grant R21CA301306
- This federal Project Grant award of $680,598 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research to understand the role of the Cullin-5 complex in regulating T cell dysfunction in cancer. The research aims to develop new therapeutic approaches to engineer T cells with durable effector function, by targeting the Cullin-5 complex to prevent T cell dysfunction caused by chronic tumor antigen stimulation. The award was provided to the...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $151,040 to The Regents of the University of California, San Francisco (UCSF) to develop improved methods for profiling cell surface proteins and proteolysis. The goal is to better understand how cancer cell surface proteins and their cleavage are remodeled by proliferative oncogenes, which could shed light on disease progression and therapeutic resistance. The project will...
- This $421,685 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate the "reactive" immune system in tumors and the tumor microenvironment. The study aims to discover discrete immune cell niches within the tumor that can enhance the effectiveness of cancer immunotherapies. Using innovative spatial transcriptomics, genetic tools, and cellular...
- This federal Project Grant award of $534,083 from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) supports research at the University of California, San Diego (UCSD) to investigate the mechanisms by which breast cancer cell-derived extracellular vesicles induce systemic glucocorticoid signaling and its effects on promoting metastasis. The key goals of the 5-year project are: (1) to identify how cancer cell extracellular vesicles enhance glucocorticoid production, (2) to...
- This $403,586 Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Virginia Commonwealth University (VCU) aims to develop a new "codon-specific isotope labeling" technology to enable improved nuclear magnetic resonance (NMR) characterization of intrinsically disordered proteins (IDPs) associated with cancer. The 2-year project focuses on optimizing the yield and incorporation efficacy of this labeling approach using the IDP EWS-FLI1, which...
- This federal Project Grant award of $590,625.00 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research conducted by the University of California, Davis to develop a novel therapeutic strategy targeting mutant p53 in cancer. The key objectives are to: Determine how mutant p53 expression is regulated by the CDK4/6-RBM38-eIF4G axis and evaluate the role of mutant p53 as a target for CDK4/6 inhibitors to suppress triple negative breast cancers (TNBCs)....
- This $667,118 Project Grant was awarded on April 1, 2025 by the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at "Identifying and Disabling New Pathways for Macromolecular Recycling in Pancreatic Cancer". The project will focus on studying the role of key lysosomal factors, including PLBD1 and LGMN, that are essential for the survival and growth of pancreatic ductal...
- This $125,834 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research by Baylor College of Medicine to investigate the role of WNT/calcium signaling in triple-negative breast cancer metastasis and chemoresistance. The project aims to establish a mouse model to directly measure intracellular calcium levels and elucidate how WNT/calcium signaling regulates tumor cell adhesion, invasion, and drug resistance. This research seeks to address...
- This federal Project Grant award of $663,340 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to elucidate the mechanisms by which the ablation of intratumoral regulatory T cells can mobilize NK cells and CD4 T cells to control MHC I-deficient tumors. The research aims to determine how CD4 T cell help enhances the antitumor function of NK cells, including the role of cytokines like IL-2 and IL-15, as well as test whether intratumoral Treg depletion...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) totaling $138,489 will support research to develop a "Methyl Arginine Targeting Chimera for the Lysosomal Degradation of Intracellular Proteins". The project aims to characterize a novel approach to targeted protein degradation that utilizes lysosomal pathways, rather than the traditional proteasomal system, to eliminate disease-causing proteins. This innovative research has the...
This federal Project Grant award of $402,400.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by the University of California, Santa Barbara (UCSB) to determine the structure-function relationship of the Wnt destruction complex, a key molecular machine involved in regulating the Wnt signaling pathway. The research project aims to gain a deeper understanding of how changes in the organization of this destruction complex condensate can impact Wnt signaling fidelity, which has implications for a variety of deadly cancers as well as other diseases driven by Wnt pathway dysregulation. The work will leverage advanced techniques such as endogenous CRISPR tagging, super-resolution microscopy, and computational modeling to provide detailed mechanistic insights. This research has the potential to inform the development of much-needed therapeutics targeting the Wnt pathway.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $402.4k | 8/14/25 |