Project Grant R21CA304761
- This $149,394 Project Grant was awarded on August 1, 2025 by the National Cancer Institute (NCI), part of the Department of Health and Human Services, under the federal Cancer Detection and Diagnosis Research program (CFDA 93.394). The grant supports research led by the University of California, Davis to advance the development of targeted radiopharmaceuticals for cancer diagnosis and therapy. Specifically, the research focuses on designing, synthesizing, and optimizing novel molecular imaging...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This $576,493.00 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop sophisticated, self-calibrating near-infrared fluorescent probes that can quantitatively assess microviscosity variations and monitor protein misfolding/aggregation within live cells. The probes are designed to have enhanced water solubility, stability, and cell permeability to maximize biocompatibility and selectivity for detecting viscosity changes and protein...
- The federal Project Grant award of $186,250.00 was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Virginia to develop and characterize membrane-sensitive fluorescent probes for measuring local membrane environments of membrane proteins in living cells. The key objectives are to: 1) calibrate various fluorescent sensors to specific membrane structural parameters and determine their spatial sensing range, and 2) demonstrate proof-of-concept...
- This Project Grant award for $450,904 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support the development of a single-cell (phospho-)proteomics platform at the Pacific Northwest National Laboratory, operated by Battelle Memorial Institute. The platform aims to address key challenges in single-cell proteomics analysis, including low recovery for phospho-enrichment, insufficient mass spectrometry sensitivity, and low sample throughput. This new platform will...
- This $462,153 Project Grant was awarded on September 4, 2025 by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to Northern Michigan University (NMU). The grant will fund the development and utilization of a novel genetically encoded fluorescent biosensor, D2HGLO, to quantify intracellular concentrations of the oncometabolite d-2-hydroxyglutarate (d-2-HG) in cancer cells. This innovative tool will allow researchers to study the subcellular localization and...
- This $379,981 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to develop a localized cancer immunotherapy using particle-anchored cytokines for prolonged intratumoral retention. The primary objectives are to: (I) develop liposome-anchored cytokines with extended tumor retention and minimal systemic leakage, and (II) elucidate the mechanisms by which particle-anchored cytokines elicit durable anti-tumor immunity to improve efficacy in poorly...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $218,886 to The Trustees of Columbia University in the City of New York to develop a new light-activated technology for targeted protein degradation in cancer cells. The project aims to optimize a photocatalytic system that can selectively degrade cancer proteins, such as the immune checkpoint receptor PD-1 and the oncogenic phosphatase SHP2, using deep red light to initiate targeted...
- This federal Project Grant award, valued at $401,829.00 and awarded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports innovative research by Weill Medical College of Cornell University to develop transformative methods for high-throughput single-cell mapping of DNA-binding proteins. The project, titled "Precision Single-Cell Mapping of Chromatin-Associated Protein Activity by Molecular Footprinting to Chart Disruptions to Gene Regulation...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $632,300 to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at subcellular resolution. The goal is to advance the application of spatial biology in cancer research by visualizing...
This $403,586 Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Virginia Commonwealth University (VCU) aims to develop a new "codon-specific isotope labeling" technology to enable improved nuclear magnetic resonance (NMR) characterization of intrinsically disordered proteins (IDPs) associated with cancer. The 2-year project focuses on optimizing the yield and incorporation efficacy of this labeling approach using the IDP EWS-FLI1, which is a driver of Ewing sarcoma, as a model target. The goal is to establish this technology to facilitate NMR-based structural analysis of IDPs, which account for over 30% of cancer-associated pathways but currently lack detailed structural information that hinders rational drug discovery efforts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $403.6k | 8/1/25 |