This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to Baylor College of Medicine totals $125,834 and is intended to fund research exploring the role of WNT/Ca2+ signaling in triple-negative breast cancer metastasis and chemoresistance. The project aims to establish a mouse model to directly measure intracellular Ca2+ levels and unravel the WNT/Ca2+ signaling pathway in triple-negative breast cancer. Specifically, the research will investigate how WNT/Ca2+ signaling modulates tumor cell-endothelium adhesion and invasion, as well as the molecular mechanisms and therapeutic vulnerabilities associated with Ca2+ inhibition to overcome chemoresistance. The award period runs from Mar 7, 2025 to Feb 28, 2027.
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