This $667,118 five-year Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) supports research by the University of California, San Francisco (UCSF) to identify and target key lysosomal proteins that enable the growth and metastasis of pancreatic ductal adenocarcinoma (PDAC), an incurable form of pancreatic cancer. The primary objectives are to: 1) explore the role of the lysosomal hydrolase PLBD1 in supporting PDAC cell metabolism by removing branched-chain amino acids from substrates, 2) dissect how the lysosomal hydrolase LGMN enables metastatic PDAC growth in the liver by breaking down liver-specific macromolecular substrates, and 3) develop small-molecule inhibitors targeting PLBD1 and LGMN as potential PDAC therapeutics. This research aims to uncover critical lysosomal vulnerabilities in PDAC that could be exploited for more effective treatment strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $667.1k | 3/25/25 |