Project Grant R01CA292660

Award Date 3/1/25
Completion Date 2/28/30
Dollars Obligated $591K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
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The key objectives are to: 1) determine how mutant p53 expression is regulated by the CDK4/6-RBM38-eIF4G axis and the role of mutant p53 as a target of CDK4/6 inhibitors to suppress mutant p53-expressing TNBCs; 2) determine whether disrupting the RBM38-eIF4G interaction can suppress mutant p53 expression and mutant p53-expressing tumors; and 3) determine whether a small molecule compound called 094-63 can block DNA damage-induced mutant p53 expression and sensitize mutant p53-expressing tumors to DNA-damaging drugs. The award period is from March 1, 2025 to February 28, 2030.

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