Project Grant R21CA299548
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $249,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective January 1, 2026 through December 31, 2028. The project, "Large-Scale Artificial Intelligence Using Radiomics, Deep Learning, and Physics-Based Generative Modeling to Improve Clinical Outcomes in Nuclear Medicine," will develop AI-driven tools to enhance cancer detection and diagnosis...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $477,674 Project Grant to The Johns Hopkins University, effective June 1, 2026 through May 31, 2031, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This research initiative focuses on molecular imaging of the immune-suppressive tumor microenvironment (TME) in prostate cancer and its response to immune checkpoint inhibitor (CIT) therapy. The project will employ molecular and functional imaging...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $399,829 under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period July 1, 2026 through June 30, 2028. The award supports development of Vascular Expansion Microscopy (VascExM), a novel imaging technique that combines expansion microscopy with light sheet microscopy to enable high-resolution optical visualization of brain vasculature at the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $130,301 on September 5, 2025, under the Cancer Cause and Prevention Research program (CFDA 93.393). The award supports research extending the Surveillance, Epidemiology, and End Results (SEER)-Medicare Database, a critical population-based health services resource that links Medicare claims data with cancer registry enrollment information. The research will leverage...
- Federal Grant Award Summary The National Cancer Institute awarded a $100,228 Project Grant to The Johns Hopkins University under the Cancer Research Manpower program (CFDA 93.398) beginning December 1, 2026 and concluding November 30, 2029. This award supports research focused on engineering and optimizing mRNA-lipid nanoparticle (mRNA-LNP) vaccine compositions to enhance tissue-specific antitumor immunity. The research aims to develop cancer vaccines that can direct immune responses and...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $354,658 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025 through July 31, 2030. This award supports fundamental research investigating subclonal P27 (CDKN1B) loss as a driver of aggressive prostate cancer, with particular focus on understanding health disparities affecting Black or African American males who experience prostate cancer mortality...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under its Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded $674,339 to the University of Pennsylvania on June 1, 2026, for a five-year project extending through May 31, 2031. The research focuses on developing translational imaging markers to enhance immunotherapy efficacy in triple-negative breast cancer (TNBC) by targeting glutamine metabolism. The project will validate the use of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $155,479 Project Grant effective June 1, 2026 through May 31, 2028 under the Cancer Treatment Research program (CFDA 93.395) to develop and validate an anti-CCRL2 (C-C motif receptor-like 2) antibody-drug conjugate (ADC) targeting high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with TP53 mutations. The research addresses a critical clinical need, as patients with...
The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,829 Project Grant effective July 1, 2026 through June 30, 2028 under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This research initiative focuses on identifying imaging biomarkers using multiplexed digital pathology data to predict clinical outcomes in breast cancer, with particular emphasis on triple-negative breast cancer (TNBC). The project applies an integrative computational approach to analyze spatially resolved, high-throughput single-cell data from tumor microenvironments, enabling data-driven identification of clinically relevant imaging biomarkers that could advance immunotherapy response prediction and treatment efficacy. The research addresses a critical unmet medical need in oncology, as current immunotherapies benefit only a subset of breast cancer patients despite recent advances with agents such as pembrolizumab. By leveraging advanced computational methods to systematically analyze the complex immune architecture and cellular interactions within tumor microenvironments, this project aims to develop novel diagnostic tools and therapeutic targets applicable across all breast cancer subtypes. The work will be conducted at The Johns Hopkins University's Baltimore, MD facility, positioning the institution's extensive biomedical research infrastructure and expertise to deliver insights that could improve patient stratification and treatment outcomes in breast cancer care.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.8k | 6/30/26 |