This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $526,174 to Duke University to engineer heterocellular human skeletal muscle tissues. The goal is to recreate and study the native stem cell niche function of healthy skeletal muscle, which is critical for its regenerative capacity. By incorporating capillary networks and functional...
This Project Grant award of $248,724.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of cellular senescence in skeletal muscle loss and dysfunction. The primary objectives are to: 1) obtain experimental skills and career training to develop a translational research program on mechanisms underlying skeletal muscle wasting,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the federal Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $473,377 to the University of California, Irvine to conduct research aimed at improving skeletal muscle regeneration through modulation of the stem cell niche. The key focus is on understanding how human pluripotent stem cells (hPSCs) can be directed to mature into functional muscle...
This $193,188 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to investigate the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction and systemic inflammation in sepsis. The central hypothesis is that knockout of the MPT-promoting protein cyclophilin D in skeletal muscle will attenuate both muscle...
This $531,109 R01 project grant, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop technologies to enable safe and effective gene editing in skeletal muscle. The University of Florida is the awardee and will focus on addressing key challenges in using adeno-associated virus (AAV) for delivering gene editing machinery to skeletal muscle, including...
This Project Grant award of $1,034,838 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the regulation of muscle stem cell niches and their role in skeletal muscle regeneration. The overarching goal is to investigate the physiological function of neutrophil serine proteases in the muscle stem cell niche and decipher the underlying molecular...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $525,048 to support research on developing and optimizing skeletal muscle delivery vehicles for gene therapy. The key research objectives are: 1) Identifying an optimal dosing strategy for lentiviruses pseudotyped with the muscle fusogenic proteins myomaker and myomerger, 2)...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to investigate a novel set of Hox-expressing interstitial cells and their potential role in muscle growth, homeostasis, and regeneration. The $557,357 award to the University of Wisconsin-Madison will support a 5-year research project that aims to interrogate the lineage potential...
This federal Project Grant award in the amount of $439,791 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will support research at The University of Texas Southwestern Medical Center to investigate the molecular mechanisms underlying myoblast fusion, a critical process for skeletal muscle development and regeneration. Key focus areas include...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $488,575.00 to the University of Arizona over a period from April 10, 2025 to March 31, 2030. The grant supports research to understand how myosin binding protein-C (MyBP-C) regulates skeletal muscle contraction and how genetic mutations in slow and fast MyBP-C paralogs lead...