Project Grant R21AI203618
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $172,220 on November 3, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support structural and mechanistic research into HIV-1 Rev nucleocytoplasmic trafficking as a potential target for novel antiretroviral drug development. The research investigates how the HIV-1 Rev protein, which mediates nuclear export of viral messenger RNA necessary for virus...
- The National Institute of Allergy and Infectious Diseases, a division of the Department of Health and Human Services, awarded the University of California, San Diego $198,793 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study the impact of exogenous estrogen on innate immune responses in individuals with HIV. The research defines how estradiol affects innate immune regulation, focusing on plasmacytoid dendritic cells, natural killer cells, and...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, Baltimore $429,753 on September 12, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct secondary analysis of human papillomavirus (HPV) persistence and immunity in transgender women and people with or at risk for HIV. The research examines the effect of gender-affirming hormone therapy and sex-steroid hormones on systemic and mucosal immune responses against anal...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $490,611 on April 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of regulatory dendritic cells in neonatal immune responses to influenza infection. The research examines how a newly identified form of dendritic cell maturation (mREGDC1) impairs protective CD8 T cell responses in newborns and young infants during respiratory viral...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $480,853 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R01AI195802) to investigate the stability and dynamics of the human anti-carbohydrate antibody repertoire across the lifespan. The research examines how chronic exposure to commensal microbiota-derived glycan determinants shapes the anti-carbohydrate (AC) B cell repertoire....
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded a cooperative agreement to the University of Maryland, Baltimore for $2,347,868 on September 20, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds a prospective human clinical trial investigating the molecular determinants of durable versus transient antibody responses following vaccination. The...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $2,461,651 to the University of Texas Health Science Center at Houston under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 18, 2025, for a project extending through July 31, 2029. The project investigates estrogen's impact on immunoglobulin G (IgG) glycomic modulation of immunity and inflammation in people with human immunodeficiency virus (HIV) on antiretroviral...
- The National Institute of Allergy and Infectious Diseases awarded Meharry Medical College $1,226,522 on May 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms governing HIV-1 immune escape mutations and host cell restriction factors. The funded research examines how HIV-1 elite controllers with human leukocyte antigen B27 maintain durable antiretroviral therapy-free viral control through potent CD8+ cytotoxic T-lymphocyte...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the University of Maryland Baltimore County $246,070 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the phosphorylation and dephosphorylation of antiretroviral drugs tenofovir and emtricitabine in colonic tissue using mass spectrometry imaging-based enzyme histochemistry. The research addresses variability in clinical...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $672,248 Project Grant (CFDA 93.855 – Allergy and Infectious Diseases Research) on September 15, 2025, to conduct a comprehensive five-year research initiative examining HIV reservoir dynamics and immune responses across the female reproductive lifespan. Led by co-principal investigators Dr. Eileen Scully (Johns Hopkins University) and Dr. Ronald Galiwango (Rakai...
The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $223,500 on July 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how menopause and menopausal hormone therapy alter immune determinants of HIV-1 susceptibility in cervical mucosa. The research integrates an ex vivo cervical explant tissue model to study infection with transmitted/founder HIV-1 strains, high-parameter spectral flow cytometry, and single-cell RNA sequencing to assess hormone-regulated immunobiology in cervical tissue obtained from pre-, peri-, and menopausal women with and without menopausal hormone therapy who undergo medically indicated hysterectomies at UAB clinics. The first aim uses 34-color flow cytometric analyses to determine how aging and hormonal decline reshape phenotypes of cervical T-cells and macrophages and to identify immune states either enhanced or diminished by hormone therapy. A second aim examines ex vivo HIV-1 infection in cervical tissue across menopausal stages. The project runs through June 30, 2028, with place of performance in Birmingham, Alabama. This assistance type is a Project Grant, supporting investigator-initiated research addressing infectious disease and related immunological challenges at a nonprofit research institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $223.5k | 7/22/26 |