Project Grant R01AI192206
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a 5-year, $1,546,730 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to support the continuation and expansion of the Johns Hopkins HIV Implementation Science Hub (Hopkins Hub). The key objectives of this award are to: 1) enhance the technical rigor of implementation science research and build capacity among investigators focused on ending...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $232,500 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Johns Hopkins University. The grant supports research to investigate the virologic determinants that lead to long-term antiretroviral therapy-free control in a subset of infants infected with HIV-1 in utero. Key research activities include: Creating infectious molecular clones...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $5,504,270 Cooperative Agreement to The Johns Hopkins University on September 26, 2025 under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The award will establish a multinational cohort of people with HIV and chronic hepatitis B (PWHHB) to apply novel technologies and advance a hepatitis B virus (HBV) functional cure. The project aims to characterize mechanisms of intrahepatic HBV...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $2,461,651.00 to the University of Texas Health Science Center at Houston to investigate the impact of estrogen on IgG glycosylation and its effects on immune function and inflammation in people with HIV. The research aims to determine if estrogen can reverse the HIV-associated loss of IgG galactose, which has been linked to reduced antiviral...
- The Thomas Jefferson University, through its Sidney Kimmel Medical College, received a $458,326 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study the function of the HIV-1 envelope glycoprotein cytoplasmic tail domain and its impact on viral trafficking and transmission. The research aims to uncover new targets for antiviral drug development, which remains critical as the AIDS pandemic continues....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $240,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Northwestern University to conduct research on characterizing the HIV-1 viral reservoirs that persist even under antiretroviral therapy (ART). The 2-year project aims to identify the cellular sources and genetic diversity of the HIV-1 reservoirs, as well as study the sources and characteristics of the residual viremia...
- This $624,902 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the impact of the HIV accessory protein Vpr on epigenetic remodeling and viral persistence in myeloid cells. The 5-year project, starting on Apr 23, 2025, will focus on characterizing how Vpr induces epigenetic changes to facilitate sustained HIV transcription and latency reactivation, as well as...
- This $118,488 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on January 20, 2025, supports research to develop HIV-resistant hematopoietic stem cells through targeted base editing. The project aims to identify genetic mutations in the CCR5 and CXCR4 co-receptors that can prevent HIV entry into CD4 cells while maintaining the central functions of these proteins in hematopoiesis. The research involves...
- This $197,366 Project Grant was awarded on March 1, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to identify the molecular mechanisms that control the natural, immune-mediated restriction of X4-tropic HIV virus, which typically emerges only in late-stage HIV disease when the immune system is impaired. The research will utilize primary CD4 T cells, in vivo analyses in...
- This five-year, $813,838 project grant from the National Institute of Allergy and Infectious Diseases will fund research into the genetic and hormonal mechanisms underlying sex differences in tuberculosis (TB) and TB-HIV coinfection. The Johns Hopkins University will investigate how X chromosome complement and sex steroid hormones impact TB pathogenesis using cellular models, animal studies, and human samples. Researchers will utilize a novel four core genotype mouse model to differentiate the...
The Johns Hopkins University was awarded a $672,248 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to study sex-specific features of the HIV reservoir and immune responses across the female reproductive lifespan in a cohort of Ugandans living with HIV. The 5-year project, which began on September 15, 2025, aims to: 1) analyze the impact of pregnancy on HIV reservoir and immunity, 2) assess HIV reservoir and immunophenotype across the menopausal transition in comparison to age-matched men, and 3) estimate epigenetic age in women and men living with HIV and assess relationships with sex and HIV reservoir activity. This research seeks to address the underrepresentation of women in HIV cure studies, particularly in Africa where the majority of women living with HIV reside.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $275.0k | 9/18/25 | ||
| Not listed | $397.3k | 9/12/25 |